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1H-1,2,4-Triazol-3-amine,5-(1,1-dimethylethyl)-(9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 202403-45-0 Structure
  • Basic information

    1. Product Name: 1H-1,2,4-Triazol-3-amine,5-(1,1-dimethylethyl)-(9CI)
    2. Synonyms: 1H-1,2,4-Triazol-3-amine,5-(1,1-dimethylethyl)-(9CI)
    3. CAS NO:202403-45-0
    4. Molecular Formula: C6H12N4
    5. Molecular Weight: 140.18628
    6. EINECS: N/A
    7. Product Categories: AMINEPRIMARY
    8. Mol File: 202403-45-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-1,2,4-Triazol-3-amine,5-(1,1-dimethylethyl)-(9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-1,2,4-Triazol-3-amine,5-(1,1-dimethylethyl)-(9CI)(202403-45-0)
    11. EPA Substance Registry System: 1H-1,2,4-Triazol-3-amine,5-(1,1-dimethylethyl)-(9CI)(202403-45-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 202403-45-0(Hazardous Substances Data)

202403-45-0 Usage

Classification

Organic compound

Type

Triazol-3-amine derivative

Use in industry

Building block for the synthesis of pharmaceutical drugs

Potential properties

Antiviral and anticancer properties

Importance

Applications in medicinal chemistry and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 202403-45-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,4,0 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 202403-45:
(8*2)+(7*0)+(6*2)+(5*4)+(4*0)+(3*3)+(2*4)+(1*5)=70
70 % 10 = 0
So 202403-45-0 is a valid CAS Registry Number.

202403-45-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-tert-butyl-1H-1,2,4-triazol-3-amine

1.2 Other means of identification

Product number -
Other names 3-tert-Butyl-1H-1,2,4-triazol-5-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:202403-45-0 SDS

202403-45-0Downstream Products

202403-45-0Relevant articles and documents

Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors

Platte, Simon,Korff, Marvin,Imberg, Lukas,Balicioglu, Ilker,Erbacher, Catharina,Will, Jonas M.,Daniliuc, Constantin G.,Karst, Uwe,Kalinin, Dmitrii V.

supporting information, p. 3672 - 3690 (2021/08/07)

Herein we report a microscale parallel synthetic approach allowing for rapid access to libraries of N-acylated aminotriazoles and screening of their inhibitory activity against factor XIIa (FXIIa) and thrombin, which are targets for antithrombotic drugs. This approach, in combination with post-screening structure optimization, yielded a potent 7 nM inhibitor of FXIIa and a 25 nM thrombin inhibitor; both compounds showed no inhibition of the other tested serine proteases. Selected N-acylated aminotriazoles exhibited anticoagulant properties in vitro influencing the intrinsic blood coagulation pathway, but not extrinsic coagulation. Mechanistic studies of FXIIa inhibition suggested that synthesized N-acylated aminotriazoles are covalent inhibitors of FXIIa. These synthesized compounds may serve as a promising starting point for the development of novel antithrombotic drugs.

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