31557-73-0Relevant articles and documents
IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AND USES THEREOF
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Page/Page column 69; 70, (2014/09/29)
The present invention relates to substituted imidazo[4,5-c]quinoline derivatives represented by the compounds formula (I), processes for their preparation, pharmaceutical compositions comprising said compounds and their use in the treatment of diseases or disorders mediated by one or more kinases (such as PI3 kinase, mTOR and ALK-1), particularly proliferative diseases or disorders such as cancer. The compounds of formula (I) can also be used in the treatment of inflammation, angiogenesis related disorders and bacterial infections.
Diastereo- and enantioselective Pd(II)-catalyzed additions of 2-alkylazaarenes to N -boc imines and nitroalkenes
Best, Daniel,Kujawa, Szymon,Lam, Hon Wai
supporting information, p. 18193 - 18196 (2013/01/15)
A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.
Condensed 4-aminopyridines with antirheumatic activity
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, (2008/06/13)
Compounds of formula I STR1 and pharmaceutically acceptable salts thereof in which one of A or B represents N and the other represents N or C--R3 ; R1 represents hydrogen, halo, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy, alkoxycarbonyl, alkanoylamino or carbamoylalkenyl; R2 represents hydrogen, alkyl, halo, alkoxy, hydroxy, alkanoyloxy, or phenoxy; R3 represents hydrogen or alkyl; R4 represents hydrogen, halo, alkoxycarbonyl, cyano, benzyloxycarbonyl, alkanoyl, benzoyl, alkyl, carboxy, alkylthio or carbamoyl; R5 represents hydrogen or alkyl; R9 represents hydrogen or alkyl; R10 represents phenyl, pyridyl or pyrimidinyl substituted by OR6 and optionally further substituted wherein R6 represents hydrogen, alkyl, alkoxycarbonyl or carbamoyl, alicyclic hydrocarbon, phenyl, cycloalkylalkyl, arylalkyl or pyridyl; or when R10 represents phenyl, OR6 represents a monosaccharide group or a disaccharide group; which are antirheumatic agents. Compositions containing these compounds and processes to prepare them are also disclosed.
STRUCTURE AND AMBIPHILIC REACTIVITY OF INDOLIZINES. 6. SCOPE OF THE ISOMERIZATIONAL RECYCLIZATION OF INDOLIZINES
Bobrovskii, S. I.,Babaev, E. V.,Bundel', Yu. G.
, p. 631 - 637 (2007/10/02)
The behavior of substituted 6- and 8-nitroindolizines in the isomerizational recyclization reaction has been examined.A novel method of synthesis of 2-acyl-5- and 7-nitroindoles has been developed, by recyclization of 3-acyl-6- and 8-nitroindolizines.The scope of the isomerizational recyclization of indolizines for the synthesis of indoles has been established.
Liquid Crystalline Compounds Bearing Pyridine Ring: Azoxy Compounds with Alkyl Substituents
Kamogawa, Hiroyoshi,Kasai, Tsuneharu,Andoh, Toshio,Nakamura, Tomoyuki
, p. 2905 - 2910 (2007/10/02)
Azoxy compounds bearing a 2,5-disubstituted pyridine ring as a principal constituent and at least one alkyl group at a molecular end were synthesized and their mesomorphic (nematic) ranges were examined.As for azoxy compounds containing an alkyl and an alkoxy group at both ends, respectively, mesomorphic ranges appeared with lower alkyl groups than those for azo compounds, their precursors.The ranges were also lower than those with both alkoxy ends.As regards an azoxy compound containing alkyl groups at both ends, no mesomorphic phenomenon appeared within the scope of this study.
