62457-94-7 Usage
Uses
Used in Pharmaceutical Industry:
(4-chlorophenyl)(1H-imidazol-2-yl)methanone is used as a pharmaceutical drug for its potential therapeutic applications. (4-chlorophenyl)(1H-imidazol-2-yl)methanone's specific characteristics may contribute to the development of new medications targeting various health conditions, given the known biological activities of imidazole derivatives.
Used in Agrochemical Industry:
In the agrochemical sector, (4-chlorophenyl)(1H-imidazol-2-yl)methanone is used as an active ingredient in the development of pesticides and other agricultural chemicals. Its incorporation into these products can help enhance crop protection and yield by targeting specific pests or diseases.
Used in Chemical Research:
(4-chlorophenyl)(1H-imidazol-2-yl)methanone also serves as a valuable compound in chemical research. Its unique structure and properties make it a candidate for further investigation, potentially leading to the discovery of new reactions, mechanisms, or applications in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 62457-94-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,4,5 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 62457-94:
(7*6)+(6*2)+(5*4)+(4*5)+(3*7)+(2*9)+(1*4)=137
137 % 10 = 7
So 62457-94-7 is a valid CAS Registry Number.
62457-94-7Relevant articles and documents
Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors
Guo, Jing,Zhao, Fan,Yin, Wenbo,Zhu, Mingyue,Hao, Chenzhou,Pang, Yu,Wu, Tianxiao,Wang, Jian,Zhao, Dongmei,Li, Haitao,Cheng, Maosheng
, p. 197 - 209 (2018/06/12)
We have previously described the identification of indolin-2-one-5-carboxamides as potent PAK4 inhibitors. This study expands the structure-activity relationships on our original series by presenting several modifications in the lead compounds, 2 and 3. A series of novel derivatives was designed, synthesized, and evaluated in biochemical and cellular assay. Most of this series displayed nanomolar biochemical activity and potent antiproliferative activity against A549 and HCT116 cells. The representative compound 10a exhibited excellent enzyme inhibition (PAK4 IC50 = 25 nM) and cellular potency (A549 IC50 = 0.58 μM, HCT116 IC50 = 0.095 μM). An X-ray structure of compound 10a bound to PAK4 was obtained. Crystallographic analysis confirmed predictions from molecular modeling and helped refine SAR results. In addition, Compound 10a displayed focused multi-targeted kinase inhibition, good calculated drug-likeness properties. Further profiling of compound 10a revealed it showed weak inhibitory activity against various isoforms of human cytochrome P450.
