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914349-75-0

5-(4-Fluorophenyl)pyridine-2-carbonitrile, a pyridine derivative with the molecular formula C13H8FN3, features a carbonitrile functional group and a fluorophenyl group attached to the second carbon atom of the pyridine ring. This versatile chemical compound is known for its potential applications in both the pharmaceutical and chemical industries due to its functional groups and structural properties.

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  • 914349-75-0 Structure

  • Basic information

    1. Product Name: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE
    2. Synonyms: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE;5-(4-Fluorophenyl)picolinonitrile
    3. CAS NO:914349-75-0
    4. Molecular Formula: C12H7FN2
    5. Molecular Weight: 198.2
    6. EINECS: N/A
    7. Product Categories: Fluorine series
    8. Mol File: 914349-75-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 359.5°C at 760 mmHg
    3. Flash Point: 171.2°C
    4. Appearance: /
    5. Density: 1.25g/cm3
    6. Vapor Pressure: 2.36E-05mmHg at 25°C
    7. Refractive Index: 1.598
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE(914349-75-0)
    12. EPA Substance Registry System: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBONITRILE(914349-75-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 914349-75-0(Hazardous Substances Data)

914349-75-0 Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Fluorophenyl)pyridine-2-carbonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its structural features allow for the creation of molecules with targeted biological activities.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(4-Fluorophenyl)pyridine-2-carbonitrile serves as an intermediate in the synthesis of agrochemicals, potentially leading to the development of new pesticides or herbicides with enhanced efficacy and selectivity.
Used in Organic Materials Development:
5-(4-Fluorophenyl)pyridine-2-carbonitrile is utilized as a building block in the development of organic materials, where its unique structure and functional groups can be leveraged to create materials with specific properties for various applications.
Used in Chemical Research:
As a compound with distinct structural elements, 5-(4-Fluorophenyl)pyridine-2-carbonitrile is also used in chemical research to explore new reactions, mechanisms, and the synthesis of novel organic compounds, contributing to the advancement of chemical science.

Check Digit Verification of cas no

The CAS Registry Mumber 914349-75-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,3,4 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 914349-75:
(8*9)+(7*1)+(6*4)+(5*3)+(4*4)+(3*9)+(2*7)+(1*5)=180
180 % 10 = 0
So 914349-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H7FN2/c13-11-4-1-9(2-5-11)10-3-6-12(7-14)15-8-10/h1-6,8H

914349-75-0Relevant articles and documents

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Greig, Iain R.,Baillie, Gemma L.,Abdelrahman, Mostafa,Trembleau, Laurent,Ross, Ruth A.

supporting information, p. 4403 - 4407 (2016/08/25)

Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive elucidation of the effects of CB1 allosteric modulation. In this study, we show a novel series of indole sulfonamides. Compounds 5e and 6c (ABD1075) had potencies of 4 and 3?nM respectively, and showed good oral exposure and CNS penetration, making them highly versatile tools for investigating the therapeutic potential of allosteric modulation of the cannabinoid system.

Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: A chemical model to describe the formation of thiazoline derivatives in human liver microsomes

Sinha, Sarmistha,Ahire, Deepak,Wagh, Santosh,Mullick, Dibakar,Sistla, Ramesh,Selvakumar, Kumaravel,Cortes, Janet Caceres,Putlur, Siva Prasad,Mandlekar, Sandhya,Johnson, Benjamin M.

, p. 2052 - 2061 (2015/02/19)

(Chemical Equation Presented) Certain aromatic nitriles are well-known inhibitors of cysteine proteases. The mode of action of these compounds involves the formation of a reversible or irreversible covalent bond between the nitrile and a thiol group in th

N- (ARYLALKYL) - 1H- INDOLE- 2 - SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

-

Page/Page column 145, (2012/09/21)

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain /V-(arylalkyl)-1 H-indole- 2-sulfonic acid amide compounds that, inter alia, inhibit cannabinoid receptor signalling. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cannabinoid receptor signalling; to treat disorders that are ameliorated by the inhibition of cannabinoid receptor signalling; to treat metabolic syndrome, type-2 diabetes, dyslipidaemia, obesity, eating disorders, cardiovascular diseases and disorders, and other conditions as described herein.

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