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CAS

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933486-45-4

Methyl 4-hydroxyquinoline-6-carboxylate is a chemical compound that belongs to the class of organic compounds known as quinolines and derivatives. It features a bicyclic heterocycle structure with a benzene ring fused to a pyridine ring, and is distinguished by the presence of a carboxylate group, classifying it as an ester. Characterized by its methyl and hydroxy functionalities, Methyl 4-hydroxyquinoline-6-carboxylate contributes to its unique chemical behavior, with properties such as melting point, boiling point, and solubility that can be ascertained through laboratory analysis. It is commonly utilized in research and may be involved in the synthesis of more complex chemical compounds.

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  • 933486-45-4 Structure

  • Basic information

    1. Product Name: Methyl 4-hydroxyquinoline-6-carboxylate
    2. Synonyms: Methyl 4-hydroxyquinoline-6-carboxylate;4-Hydroxyquinoline-6-carboxylic acid Methyl ester
    3. CAS NO:933486-45-4
    4. Molecular Formula: C11H9NO3
    5. Molecular Weight: 203.19406
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 933486-45-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 382.6±22.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.327±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 3.49±0.40(Predicted)
    10. CAS DataBase Reference: Methyl 4-hydroxyquinoline-6-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Methyl 4-hydroxyquinoline-6-carboxylate(933486-45-4)
    12. EPA Substance Registry System: Methyl 4-hydroxyquinoline-6-carboxylate(933486-45-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 933486-45-4(Hazardous Substances Data)

933486-45-4 Usage

Uses

Used in Research Applications:
Methyl 4-hydroxyquinoline-6-carboxylate is used as a research chemical for [application reason], contributing to the development and understanding of quinolines and their derivatives.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 4-hydroxyquinoline-6-carboxylate is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason], such as the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
Methyl 4-hydroxyquinoline-6-carboxylate is used as a synthetic building block for [application reason], facilitating the creation of more complex organic compounds with diverse applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 933486-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,3,4,8 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 933486-45:
(8*9)+(7*3)+(6*3)+(5*4)+(4*8)+(3*6)+(2*4)+(1*5)=194
194 % 10 = 4
So 933486-45-4 is a valid CAS Registry Number.

933486-45-4Relevant articles and documents

Cu(I)-Catalyzed Alkynylation of Quinolones

Maestro, Aitor,Lemaire, Sebastien,Harutyunyan, Syuzanna R.

supporting information, p. 1228 - 1231 (2022/02/14)

Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.

Direct C-3-alkenylation of quinolones via palladium-catalyzed C-H functionalization

Li, Mingzong,Li, Liangxi,Ge, Haibo

supporting information; experimental part, p. 2445 - 2449 (2010/12/25)

An unprecedented C-3-alkenylation of quinolones was reported through palladium-catalyzed C-H functionalization with 1% catalyst loading. This method provides an efficient route to a variety of new quinolone derivatives.

QUINOLINE DERIVATIVES

-

Page/Page column 120, (2008/06/13)

The invention concerns quinoline derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

Assembly of 4-aminoquinolines via palladium catalysis: A mild and convenient alternative to SNAr methodology

Margolis, Brandon J.,Long, Kimberly A.,Laird, Dana L. T.,Ruble, J. Craig,Pulley, Shon R.

, p. 2232 - 2235 (2007/10/03)

4-Aminoquinolines, classically prepared via SNAr chemistry from an amine and 4-haloquinoline, are important scaffolds in medicinal chemistry. Interest in these compounds prompted us to explore palladium catalysis as an alternative to the existing methods for their preparation. Initial results followed by an iterative screening paradigm confirmed Pd(OAc)2/ DPEphos/K3PO4 as a mild and convenient alternative for the formation of the C-N bond in 4-aminoquinolines. A description of the screen and the scope of this methodology are discussed herein.

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