97612-24-3 Usage
Uses
Used in Pharmaceutical Industry:
FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride is used as a dopamine receptor antagonist for its ability to block dopamine receptors in the brain. This property makes it a potential candidate for the treatment of various neurological and psychiatric disorders, such as schizophrenia, Parkinson's disease, and bipolar disorder, where dopamine receptor modulation is crucial for symptom management.
Used in Neuroscientific Research:
In astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments, FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride is used to study the interactions between astrocytes and neurons, as well as to investigate the effects of dopamine receptor antagonism on brain function. This helps researchers to better understand the underlying mechanisms of neurological disorders and develop more effective treatments.
Biological Activity
Selective dopamine D 2 /D 3 receptor antagonist (K i values are 0.50 and 0.16 nM respectively). Antipsychotic.
Biochem/physiol Actions
Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2?receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.
Check Digit Verification of cas no
The CAS Registry Mumber 97612-24-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,6,1 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 97612-24:
(7*9)+(6*7)+(5*6)+(4*1)+(3*2)+(2*2)+(1*4)=153
153 % 10 = 3
So 97612-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
97612-24-3Relevant articles and documents
Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides
de Paulis,Kumar,Johansson,Raemsby,Hall,Saellemark,Angeby-Moeller,Ogren
, p. 61 - 69 (2007/10/02)
A series of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides was synthesized, starting from the 2,6-dimethoxybenzoic acids, by boron tribromide demethylation of the corresponding 3,5-disubstituted 2,6-dimethoxybenzamides and sep
Synthesis, crystal structure and antidopaminergic properties of eticlopride (FLB 131)
De Paulis,Hall,Ogren,et al.
, p. 273 - 276 (2007/10/02)
The synthesis of the title compounds was achieved by chlorination of 3-ethyl-6-methoxysalicylic acid followed by coupling of the corresponding salicylic acid chloride with S(-)-2-aminomethyl-1-ethylpyrrolidine and S(+)-2-aminomethyl-1-triphenylmethylpyrro
