Relevant articles and documents
Aerobic oxidative dehydrogenation of N-heterocycles catalyzed by cobalt porphyrin
Zhou, Weiyou Chen, Dongwei Sun, Fu'an Qian, Junfeng He, Mingyang Chen, Qun
An efficient catalytic procedure has been developed for the aerobic oxidative dehydrogenation of N-heterocycles by cobalt porphyrin in the absence of any additives. The catalytic system could tolerate various 1,2,3,4-tetrahydroquinoline derivatives and some other N-heterocycles. The corresponding N-heteroaromatics could be obtained in 59–86% yields. The mechanism investigation suggested that the aerobic oxidative dehydrogenation might proceed with imine intermediate through radical paths.
Catalytic Asymmetric Cascade Using Spiro-Pyrrolidine Organocatalyst: Efficient Construction of Hydrophenanthridine Derivatives
Tian, Jin-Miao Yuan, Yong-Hai Xie, Yu-Yang Zhang, Shu-Yu Ma, Wen-Qiang Zhang, Fu-Min Wang, Shao-Hua Zhang, Xiao-Ming Tu, Yong-Qiang
A newly developed SPD (spiro-pyrrolidine) organocatalyst has been demonstrated to enable an asymmetric aza-Michael/Michael/aldol cyclization cascade, in which two six-membered rings (B/C) and three stereocenters have been constructed in a catalytic one-step process. It is so far the most efficient method for construction of hydrophenanthridine derivatives featuring high enantioselectivity. The trans- or cis-fused B/C-rings can be selectively assembled in a substrate-controlled manner. Moreover, this cascade could magnify to gram scale without loss of enanioselectivity.
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