215934-32-0

Basic information

• Product Name: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate
• Synonyms: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate;Bankit;Benzeneacetic acid, 2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)-, methyl ester, (E)-;Einecs annex I index 607-256-00-x;Hsdb 7017
• CAS NO: 215934-32-0
• Molecular Formula: C₂₂H₁₇N₃O₅
• Molecular Weight: 0
• Mol File: 215934-32-0.mol
• Article Data: 49

Chemical Properties

• Boiling Point: 581.3°C at 760 mmHg
• Flash Point: 305.3°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 1.67E-13mmHg at 25°C
• Refractive Index: 1.626
• Water Solubility: 6g/L at 20℃
• CAS DataBase Reference: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate(215934-32-0)
• EPA Substance Registry System: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate(215934-32-0)

Safety Data

• Hazard Codes: T:Toxic;;
• Statements: R23:; R50/53:
• Safety Statements: S22:; S45:; S60:; S61:
• Hazardous Substances Data: 215934-32-0(Hazardous Substances Data)

Usage

Description

Methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy-prop-2-enoate is a complex synthetic organic compound belonging to the class of methoxypropenoates. It features a unique structure with a methyl group attached to a 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yl)oxyphenyl)-3-methoxyprop-2-enoate moiety. methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate may hold potential for applications in the pharmaceutical industry, particularly in the development of innovative drugs that target specific cellular pathways or receptors. Further research and testing are required to determine its precise properties and uses.

Uses

Used in Pharmaceutical Industry:
Methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy-prop-2-enoate is used as a potential candidate for the development of new drugs in the pharmaceutical industry. Its unique structure and properties may allow it to target specific cellular pathways or receptors, offering novel therapeutic approaches for various diseases and conditions.
methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate's potential applications in the pharmaceutical industry could include:
1. Targeting specific cellular pathways or receptors involved in various diseases, such as cancer, inflammatory disorders, or neurological conditions.
2. Enhancing the efficacy of existing drugs by modifying their chemical structure or delivery methods.
3. Developing prodrugs that can be activated in the body to release the active compound, improving drug safety and selectivity.

InChI:InChI=1/C22H17N3O5/c1-27-13-17(22(26)28-2)16-8-4-6-10-19(16)30-21-11-20(24-14-25-21)29-18-9-5-3-7-15(18)12-23/h3-11,13-14H,1-2H3/b17-13+

Upstream product

• 143130-94-3 methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 77-78-1 dimethyl sulfate 
• 611-20-1 salicylonitrile 
• 40800-90-6 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone 
• 913846-53-4 2-[(6-chloro-4-pyrimidinyl)oxy]-benzonitrile 
• 124-41-4 sodium methylate 
• 107-31-3 Methyl formate 
• 131860-97-4 (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate 
• 74255-21-3 2-hydroxybenzonitrile sodium salt 
• 114077-42-8 (E)-3-methoxy-2-(2-hydroxyphenyl)-acrylic acid methyl ester 
• 1193-21-1 4,6-dichloropyrimidine 
• 125808-20-0 methyl 2-(2-hydroxyphenyl)-3-methoxyacrylate 
• 614-75-5 2-Hydroxyphenylacetic acid 

Downstream Products

• 143130-94-3 methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate 
• 240802-59-9 2-(6-hydroxypyrimidin-4-yloxy)benzonitrile 
• 478413-45-5 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)acetic acid methyl ester 
• 1193-24-4 4,6-pyrimidinediol 
• 1185255-09-7 (E)-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylic acid 

Relevant articles and documents

Method for improving conversion rate of azoxystrobin

The invention discloses a method for improving the conversion rate of azoxystrobin. The method comprises the following steps: preparing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate; preparing o-hydroxybenzonitrile; mixing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate, o-hydroxybenzonitrile, potassium carbonate and ketene chloride according to a molar ratio of 30: 35: 50: 1.1, and dissolving the obtained mixture in dimethylformamide to obtain a mixed product; and heating the prepared mixed product, keeping the mixed product at a certain temperature, conducting filtering, carrying out reduced-pressure distillation, performing cooling, separating out crystals, carrying out filtering and washing and performing drying to obtain azoxystrobin. On the basis of the prior art, the synthesis of azoxystrobin is improved in the invention, so the yield of azoxystrobin is effectively increased, the conversion rate of the raw materials including methyl(E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate and o-hydroxybenzonitrile for azoxystrobin in the process of preparing azoxystrobin is effectively improved, and the production benefit of azoxystrobin is improved.

MENUFCACTURING METHOD OF AZOXYSTROBIN

MCMA ((E)- Methyl methyl methyl (2- ((6-chloropyrimidin-4-yl) oxy) phenyl).3 - methoxyacrylate). DABCO (1, 4-diazabicyclo [2.2.2] octane) and 2 - CP (2-cyanophenol) are mixed and fed into a reactor (z) by mixing into azoxystobin a continuous reactor and introducing them into a reactor.

PROCESS FOR PREPARATION OF AZOXYSTROBIN AND INTERMEDIATES THEREOF

The present invention relates to a process for preparation of strobilurin compound, azoxystrobin and its intermediates using a catalyst selected from 1,8-Diazabicyclo[5.4.0]undec-7-ene or 1,5-Diazabicyclo[4.3.0]non-5-ene, salts thereof, or derivatives thereof.