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Name	1H-Imidazole-2-methanol,1-(phenylmethyl)-	EINECS	N/A
CAS No.	5376-10-3	Density	1.13 g/cm³
PSA	38.05000	LogP	1.42370
Solubility	N/A	Melting Point	89-92 °C
Formula	C₁₁H₁₂N₂O	Boiling Point	354.9 °C at 760 mmHg
Molecular Weight	188.229	Flash Point	168.4 °C
Transport Information	N/A	Appearance	N/A
Safety	26-36/37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Imidazole-2-methanol, 1-benzyl-;	Article Data	18

1H-Imidazole-2-methanol,1-(phenylmethyl)- Synthetic route

: 10045-65-5
N-benzylimidazole-2-carboxaldehyde

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; for 2.5h;	93.1%
With sodium tetrahydroborate In methanol at 0℃; for 2.5h;
With methanol; sodium tetrahydroborate at 0 - 20℃;

: 4238-71-5
1-benzylimidazole

: 50-00-0
formaldehyd

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

Conditions

Conditions	Yield
In water at 150℃; for 3h;	92%
In water for 72h; Heating;	56%
In 1,4-dioxane at 135℃; under 5250.53 Torr; for 20h; Autoclave;	50%

: 4238-71-5
1-benzylimidazole

: 50-00-0
formaldehyd

A: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

B: 115960-26-4
1-benzylimidazole-2,5-dimethanol

C: 118599-62-5
1-benzylimidazole-2,4,5-trimethanol

Conditions

Conditions	Yield
With sodium acetate In water; acetic acid at 140℃; for 12h;	A 10% B 20% C 5%

: 4238-71-5
1-benzylimidazole

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) n-BuLi / 1.) Et2O, hexane, -45 deg C, 30 min, 2 a.) -75 deg C, b.) 0 deg C, 10 min 2: NaBH4 / methanol / 2.5 h / 0 °C View Scheme
With sodium hydroxide; formaldehyd
With sodium hydroxide; formaldehyd

: 23269-10-5
1-benzyl-1H-imidazole-2-thione

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous HNO3 View Scheme

: 61190-10-1
N-benzyl-N-(2,2-diethoxyethyl)amine

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ethanol; aqueous HCl 2: aqueous HNO3 View Scheme
Multi-step reaction with 3 steps 1: ethanol; aqueous HCl 2: aqueous HNO3 View Scheme

: 100-39-0
benzyl bromide

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium hydroxide / acetone / 2 h 2: sodium tetrahydroborate / methanol / 2.5 h / 0 °C View Scheme

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

: 19276-03-0
1-(phenylmethyl)-2-chloromethyl-1H-imidazole monohydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform for 2h; Heating;	95%
Multi-step reaction with 2 steps 1: HCl / CH2Cl2 2: SOCl2 / 0.5 h / Ambient temperature View Scheme
With thionyl chloride In dichloromethane
With thionyl chloride In dichloromethane

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

: cadmium(II) nitrate tetrhydrate

: [Cd(1-benzyl-2-hydroxymethylimidazole)4](NO3)2(H2O)2

Conditions

Conditions	Yield
In methanol; water soln. of ligand in MeOH stirred with aq. soln. of metal salt in molar ratio of 4:1; crystd. at room temp. for 1 wk, filtered, dried in vac.; elem. anal.;	88%

: 5376-10-3
1-benzyl-2-(hydroxymethyl)imidazole

: 110-75-8
2-chloroetyl vinyl ether

: 959857-27-3
1-benzyl-2-(vinyloxyethyloxymethyl)imidazole

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water; toluene at 90℃; for 24h;	87%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In toluene at 90℃; for 24h;	85%

1H-Imidazole-2-methanol,1-(phenylmethyl)- Specification

The 1H-Imidazole-2-methanol,1-(phenylmethyl)-, with the CAS registry number 5376-10-3, is also known as Imidazole-2-methanol, 1-benzyl-. This chemical's molecular formula is C₁₁H₁₂N₂O and molecular weight is 188.2258. What's more, both its IUPAC name and systematic name are the same which is called (1-Benzyl-1H-imidazol-2-yl)-methanol.

Physical properties about 1H-Imidazole-2-methanol,1-(phenylmethyl)- are: (1)ACD/LogP: 0.97; (2)#of Rule of 5 Violations: 0; (3)#H bond acceptors: 3; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 4; (6) Polar Surface Area: 27.05Å²; (7)Index of Refraction: 1.592; (8) Molar Refractivity: 56 cm³; (9)Molar Volume: 165.4 cm³; (10)Surface Tension: 45.2 dyne/cm; (11)Density: 1.13 g/cm³; (12)Flash Point: 168.4 °C; (13)Enthalpy of Vaporization: 63.31 kJ/mol; (14)Boiling Point: 354.9 °C at 760 mmHg; (15)Vapour Pressure: 1.19E-05 mmHg at 25 °C; (16)Melting Point: 89-92 °C.

When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system and skin. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: OCc1nccn1Cc2ccccc2
(2) InChI: InChI=1/C11H12N2O/c14-9-11-12-6-7-13(11)8-10-4-2-1-3-5-10/h1-7,14H,8-9H2
(3) InChIKey: SGIKRGDBBXWNRI-UHFFFAOYAW

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