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Cas Database |
| Name |
1H-Indazol-5-ol |
EINECS | N/A |
| CAS No. | 15579-15-4 | Density | 1.434 g/cm3 |
| PSA | 48.91000 | LogP | 1.26850 |
| Solubility | N/A | Melting Point |
186-191°C |
| Formula | C7H6N2O | Boiling Point | 366.5 °C at 760 mmHg |
| Molecular Weight | 134.137 | Flash Point | 175.5 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26-39 | Risk Codes | 22-41 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
5-Indazolol(5CI);5-Hydroxy-1H-indazole;5-Hydroxyindazole;NSC 520104; |
Article Data | 10 |
1H-Indazol-5-ol Synthetic route
- 94444-96-9
5-methoxy-1H-indazole
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| With boron tribromide In dichloromethane at 20℃; for 10h; | 71% |
- 19335-11-6
1H-indazol-5-ylamine
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| With sulfuric acid at 170 - 180℃; | |
| With sulfuric acid at 200 - 205℃; unter Druck; | |
| Stage #1: 1H-indazol-5-ylamine With sulfuric acid In water at 180℃; for 15h; Stage #2: With sodium hydroxide In water pH=> 10; |
- 36174-07-9
N,O-diacetyl-5-hydroxy-1H-indazole
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol at 80℃; for 5h; | 7.99 g |
- 2835-99-6
4-amino-3-methylphenol
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: potassium acetate; isoamyl nitrite / CHCl3 / 18 h / 80 °C 2: 7.99 g / HCl / methanol / 5 h / 80 °C View Scheme |
- 5401-94-5
5-nitroindazole
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: Raney nickel / Hydrogenation 2: aqueous H2SO4 / 170 - 180 °C View Scheme |
- 543-87-3
isopentyl nitrate
- 2835-99-6
4-amino-3-methylphenol
- 144-55-8
sodium hydrogencarbonate
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| With potassium acetate; acetic anhydride In hydrochloric acid-methanol; water; chlorobenzene |
- 102-50-1
2-methyl-4-methoxyaniline
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: acetic acid; sodium nitrite / water / 20 °C 2: boron tribromide / dichloromethane / 10 h / 20 °C View Scheme |
- 15579-15-4
5-hydroxy-1H-indazole
- 18162-48-6
tert-butyldimethylsilyl chloride
- 1254473-74-9
5-(tert-butyl-dimethyl-silanyloxy)-1H-indazole
| Conditions | Yield |
|---|---|
| With 1H-imidazole In N,N-dimethyl-formamide at 0 - 18℃; for 3.5h; | 100% |
| With 1H-imidazole In N,N-dimethyl-formamide at 0 - 18℃; for 3.5h; | 100% |
| With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 18h; | 99% |
| Conditions | Yield |
|---|---|
| Stage #1: 5-hydroxy-1H-indazole; ethyl bromoacetate With potassium carbonate In acetone for 16h; Inert atmosphere; Reflux; Stage #2: With sodium hydroxide In methanol at 20℃; for 3h; Inert atmosphere; | 99% |
- 15579-15-4
5-hydroxy-1H-indazole
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide In tetrahydrofuran at 20℃; for 14h; | 91% |
| With N-Bromosuccinimide In tetrahydrofuran at 25℃; for 12h; | 90% |
1H-Indazol-5-ol Chemical Properties
IUPAC Name: 1H-indazol-5-ol
Synonyms of 1H-Indazol-5-ol (CAS NO.15579-15-4): 5-Hydroxy indazole ; Hydroxy-5 indazole
Product Categories: Alcohols and Derivatives;Heterocycles;pharmacetical
CAS NO: 15579-15-4
Molecular Formula: C7H6N2O
Molecular Weight : 134.135340 g/mol
Molecular Structure: 
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 27.05Å2
Index of Refraction: 1.76
Molar Refractivity: 38.5 cm3
Molar Volume: 93.5 cm3
Surface Tension: 80.1 dyne/cm
Density: 1.434 g/cm3
Flash Point: 175.5 °C
Enthalpy of Vaporization: 63.7 kJ/mol
Boiling Point: 366.5 °C at 760 mmHg
Vapour Pressure: 6.9E-06 mmHg at 25°C
1H-Indazol-5-ol Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 1gm/kg (1000mg/kg) | French Medicament Patent Document. Vol. #7631M, |
1H-Indazol-5-ol Safety Profile
Hazard Cods: 
Xi
Hazard Note: Irritant
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