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Name	2',6'-Pipecoloxylidide	EINECS	605-165-8
CAS No.	15883-20-2	Density	1.087 g/cm³
PSA	41.13000	LogP	2.78580
Solubility	N/A	Melting Point	114-117 ºC
Formula	C₁₄H₂₀N₂O	Boiling Point	392.3 ºC at 760 mmHg
Molecular Weight	232.326	Flash Point	149 ºC
Transport Information	N/A	Appearance	Off-white to light yellow powder
Safety	45	Risk Codes	25
Molecular Structure		Hazard Symbols	Xi
Synonyms	N-(2',6'-dimethylphenl)-2-Piperidine;2',6'-Pipecoloxylidide(6CI,7CI,8CI);Debutylbupivacaine;Desbutylbupivacaine;N-Desbutylbupivacaine;	Article Data	18

2',6'-Pipecoloxylidide Chemical Properties

IUPAC Name: N-(2,6-Dimethylphenyl)piperidine-2-carboxamide
Synonyms of 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)- (CAS NO.15883-20-2): 2',6'-Pipecolylxylidine ; 4-22-00-00098 (Beilstein Handbook Reference) ; BRN 0206391 ; Demethylmepivacaine ; Desbutylbupivacaine ; N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide ; N-Desbutylbupivacaine ; Piperidine-2-carboxylic acid 2,6-dimethylanilide ; 2',6'-Pipecoloxylidide (6CI,7CI,8CI)
CAS NO: 15883-20-2
Classification Code: Drug / Therapeutic Agent
Molecular Formula: C₁₄H₂₀N₂O
Molecular Weight: 232.3214
Molecular Structure:

Melting Point: 114-117 °C
Polar Surface Area: 23.55 Å²
Index of Refraction: 1.567
Molar Refractivity: 69.8 cm³
Molar Volume: 213.6 cm³
Surface Tension: 44.1 dyne/cm
Density of 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)- (CAS NO.15883-20-2): 1.087 g/cm³
Flash Point: 149 °C
Enthalpy of Vaporization: 64.2 kJ/mol
Boiling Point: 392.3 °C at 760 mmHg
Vapour Pressure: 2.31E-06 mmHg at 25°C

2',6'-Pipecoloxylidide Uses

2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)- (CAS NO.15883-20-2) is used as a major metabolite of Bupivacaine and Ropivacaine.

2',6'-Pipecoloxylidide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	140mg/kg (140mg/kg)		Clinical and Experimental Pharmacology and Physiology. Vol. 21, Pg. 997, 1994.
mouse	LD50	intravenous	45mg/kg (45mg/kg)		European Patent Application. Vol. #0155176,

2',6'-Pipecoloxylidide Safety Profile

Hazard Codes of 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)- (CAS NO.15883-20-2): Irritant Xi

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