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2-Amino-4-chloropyridine
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Name

2-Amino-4-chloropyridine

 EINECS -0
CAS No. 19798-80-2 Density 1.327 g/cm3
PSA 38.91000 LogP 1.89840
Solubility N/A Melting Point 126-127 °C
Formula C5H5ClN2 Boiling Point 240.793 °C at 760 mmHg
Molecular Weight 128.561 Flash Point 99.428 °C
Transport Information N/A Appearance light yellow cryst
Safety 26 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 19798-80-2 (2-Amino-4-chloropyridine) Hazard Symbols IrritantXi,HarmfulXn
Synonyms

4-chloro-1H-pyridin-2-amine;4-Chloro-pyridin-2-ylamine;4-chloro-2-aminopyridine;4-chloropyridin-2-amine;4-Chloro-2-amine-pyridine;2-Amino-4-chloro pyridine/2-Amino-6-chloro pyridine;4-Chloro-2-amine-pyridin;

Article Data 32

2-Amino-4-chloropyridine Synthetic route

130721-78-7

tert-butyl (4-chloropyridin-2-yl) carbamate

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h;100%
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h;99%
With trifluoroacetic acid In dichloromethane at 20℃;90%
With hydrogen bromide for 2h;87%
With hydrogen bromide for 2h; Ambient temperature;
74405-00-8

2,2-dimethyl-3-(4-chloropyrid-2-yl)-4-oxo-4H-1,3-benzoxazine

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With hydrogenchloride for 8h; Heating;95%
With hydrogenchloride Hydrolysis;
99586-65-9

4-chloropicolinamide

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With bromine; potassium hydroxide In water at 90℃; for 2h; Cooling with ice;84%
With calcium hypochlorite In water at 60 - 80℃; Temperature;81%
With sodium hydroxide; bromine In water at 80℃; for 1.5h; Hofmann Degradation;64%

methyl 4-chloropyridine-2-carboxylate hydrochloride

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With hydrazine hydrate; sodium nitrite In hydrogenchloride; methanol; water; acetic acid44%
With hydrazine hydrate; acetic acid; sodium nitrite In hydrogenchloride; methanol; water37 g (60%)
26452-80-2

2,4-dichloropyridine

A

19798-80-2

2-Amino-4-chloropyridine

B

14432-12-3

4-Amino-2-chloropyridine

Conditions
ConditionsYield
With ammonium hydroxide at 170 - 180℃;
With ammonium hydroxide at 180℃;
187973-17-7

4-chloro-pyridine-2-carbonyl azide

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With acetic acid

N-(4-chloro-2-pyridyl)-1-(2-pyridyl)-1-chloroacetamide

A

19798-80-2

2-Amino-4-chloropyridine

B

α-chloro-(2-pyridyl)acetic acid

Conditions
ConditionsYield
With hydrogenchloride at 60℃; for 3h;A 70 mg
B 45 mg
1026394-00-2

4-chloro-2-pyridinylisocyanate

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With hydrogenchloride for 48h; Heating; Yield given;
73771-11-6

4-chloropyridine-2-carbohydrazide

19798-80-2

2-Amino-4-chloropyridine

Conditions
ConditionsYield
With hydrogenchloride; acetic acid; sodium nitrite 1.) water, 15 min, 2.) water, heating; Yield given. Multistep reaction;
26452-80-2

2,4-dichloropyridine

ammonium hydroxide

A

19798-80-2

2-Amino-4-chloropyridine

B

14432-12-3

4-Amino-2-chloropyridine

Conditions
ConditionsYield
at 180℃;

2-Amino-4-chloropyridine Specification

The 4-Chloro-pyridin-2-ylamine is an organic compound with the formula C5H5ClN2. The IUPAC name of this chemical is 4-chloropyridin-2-amine. With the CAS registry number 19798-80-2, it is also named as 2-Pyridinamine, 4-chloro-. The product's categories are Pyridine; Blocks; Pyridines; Amines and Anilines; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Heterocyclic Series; Pharmacetical; Pyridine Series; Amines; Nucleotides and Nucleosides; Bases & Related Reagents; Nucleotides; Pharmaceutical Intermediate; Amino-Pyridine Eeries.

Physical properties about 4-Chloro-pyridin-2-ylamine are: (1)ACD/LogP: 1.32; (2)ACD/LogD (pH 5.5): 0.897; (3)ACD/LogD (pH 7.4): 1.308; (4)ACD/BCF (pH 5.5): 2.244; (5)ACD/BCF (pH 7.4): 5.785; (6)ACD/KOC (pH 5.5): 47.149; (7)ACD/KOC (pH 7.4): 121.544; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)Polar Surface Area: 38.91 Å2; (11)Index of Refraction: 1.607; (12)Molar Refractivity: 33.475 cm3; (13)Molar Volume: 96.888 cm3; (14)Polarizability: 13.271×10-24cm3; (15)Surface Tension: 54.396 dyne/cm; (16)Density: 1.327 g/cm3; (17)Flash Point: 99.428 °C; (18)Enthalpy of Vaporization: 47.772 kJ/mol; (19)Boiling Point: 240.793 °C at 760 mmHg; (20)Vapour Pressure: 0.037 mmHg at 25°C.

Preparation: this chemical can be prepared by t-butyl N-(4-chloro-2-pyridinyl)carbamate. This reaction will need reagent 25 percent HBr. The reaction time is 2 hours. The yield is about 87%.



Uses of 4-Chloro-pyridin-2-ylamine: it can be used to produce 4-methoxy-pyridin-2-ylamine at temperature of 140 °C. It will need solvent methanol with reaction time of 7 hours. The yield is about 44%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cnc(cc1Cl)N
(2)InChI: InChI=1/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
(3)InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
(5)Std. InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYSA-N

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