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Cas Database |
| Name |
2-Bromo-5-chloropyridine |
EINECS | N/A |
| CAS No. | 40473-01-6 | Density | 1.736 g/cm3 |
| PSA | 12.89000 | LogP | 2.49750 |
| Solubility | Slightly soluble in water. | Melting Point |
65-69 °C |
| Formula | C5H3BrClN | Boiling Point | 212 °C at 760 mmHg |
| Molecular Weight | 192.443 | Flash Point | 82 °C |
| Transport Information | N/A | Appearance | white to light yellow crystal powder |
| Safety | 36/37/39-26-22 | Risk Codes | 36/37/38-20/22-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xi,  Xn
|
| Synonyms |
2-bromo-5-chloro-pyridine; |
Article Data | 17 |
2-Bromo-5-chloropyridine Synthetic route
- 1072-98-6
5-chloro-2-pyridylamine
- 40473-01-6
2-Bromo-5-chloro-pyridine
| Conditions | Yield |
|---|---|
| With hydrogen bromide; bromine; sodium nitrite In water at 0 - 10℃; for 1.5h; | 93% |
| Stage #1: 5-chloro-2-pyridylamine With hydrogen bromide; bromine; sodium nitrite In water at 0℃; for 1h; Stage #2: With sodium hydroxide In water; ethyl acetate | 91% |
| With hydrogen bromide; bromine; sodium nitrite In water at 0℃; for 1h; | 91% |
- 1072-98-6
5-chloro-2-pyridylamine
A
- 40473-01-6
2-Bromo-5-chloro-pyridine
B
- 2516-40-7
2-bromo-1,3-benzothiazole
| Conditions | Yield |
|---|---|
| A 70% B n/a |
- 16110-09-1
2,5 dichloropyridine
- 40473-01-6
2-Bromo-5-chloro-pyridine
| Conditions | Yield |
|---|---|
| With trimethylsilyl bromide In various solvent(s) Heating; | 67% |
- 4214-79-3
5-chloro-2-pyridinol
- 40473-01-6
2-Bromo-5-chloro-pyridine
| Conditions | Yield |
|---|---|
| With phosphorus(V) oxybromide for 16h; Heating / reflux; |
- 40473-01-6
2-Bromo-5-chloro-pyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: polyphosphoric acid / 0.08 h / 160 - 180 °C 2: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C View Scheme |
- 40473-01-6
2-Bromo-5-chloro-pyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: polyphosphoric acid / 0.08 h / 160 - 180 °C 2: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C View Scheme |
- 40473-01-6
2-Bromo-5-chloro-pyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: polyphosphoric acid / 0.08 h / 160 - 180 °C 2: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C View Scheme |
| Conditions | Yield |
|---|---|
| With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction; | 98% |
- 40473-01-6
2-Bromo-5-chloro-pyridine
- 453568-66-6
3-(5-bromofuran-2-yl)-benzonitrile
- 453568-67-7
3-(5-(5-choro-2-pyridyl)-2-furyl)-benzonitrile
| Conditions | Yield |
|---|---|
| With hexamethyldistannane; Pd(PPh3)4 In hexane; dichloromethane; chloroform; ethyl acetate | 97.5% |
- 40473-01-6
2-Bromo-5-chloro-pyridine
- 5575-51-9
tris(4-chlorophenyl)bismuthane
| Conditions | Yield |
|---|---|
| With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction; | 96% |
2-Bromo-5-chloropyridine Specification
The 2-Bromo-5-chloropyridine is an organic compound with the formula C5H3BrClN. The IUPAC name of this chemical is 2-bromo-5-chloropyridine. With the CAS registry number 40473-01-6, it is also named as 5-Chloro-2-bromo-pyridine. The product's categories are blocks; Bromides; Pyridines; Pyridine; Pyridine Series; Pyridines, Pyrimidines, Purines and Pteredines; Halides; B romopyridines; Chloropyridines; Halopyridines; Boronic Acid. Besides, it is a white to light yellow crystal powder, which should be stored in a closed cool and dry place.
Physical properties about 2-Bromo-5-chloropyridine are: (1)ACD/LogP: 2.31; (2)#H bond acceptors: 1; (3)Polar Surface Area: 12.89 ?2; (4)Index of Refraction: 1.581; (5)Molar Refractivity: 36.92 cm3; (6)Molar Volume: 110.7 cm3; (7)Polarizability: 14.63×10-24cm3; (8)Surface Tension: 45.5 dyne/cm; (9)Density: 1.736 g/cm3; (10)Flash Point: 82 °C; (11)Enthalpy of Vaporization: 43.01 kJ/mol; (12)Boiling Point: 212 °C at 760 mmHg; (13)Vapour Pressure: 0.257 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection and do not breathe dust.
You can still convert the following datas into molecular structure:
(1)SMILES: c1cc(ncc1Cl)Br
(2)InChI: InChI=1/C5H3BrClN/c6-5-2-1-4(7)3-8-5/h1-3H
(3)InChIKey: BZUUVQCSPHPUQA-UHFFFAOYAL
(4)Std. InChI: InChI=1S/C5H3BrClN/c6-5-2-1-4(7)3-8-5/h1-3H
(5)Std. InChIKey: BZUUVQCSPHPUQA-UHFFFAOYSA-N
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