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Conditions | Yield |
---|---|
With sodium azide; triphenylphosphine In dichloromethane; N,N-dimethyl-formamide at 90℃; for 5h; Substitution; Mitsunobu reaction; Staudinger reaction; | 92% |
With Ru(CO)ClH(oxydi-2,1-phenylene)bis(diphenylphosphine)(triphenylphosphine); ammonia In toluene at 170℃; for 48h; Autoclave; Glovebox; Inert atmosphere; | 77 %Spectr. |
Conditions | Yield |
---|---|
With ammonia; hydrogen; nickel at 140℃; |
Conditions | Yield |
---|---|
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); ammonia; water In tert-Amyl alcohol; tert-butyl methyl ether at 170℃; for 16h; pressure tube; Inert atmosphere; | 70 %Chromat. |
2-ethyl-hexanal oxime
2-Ethylhexylamine
Conditions | Yield |
---|---|
Stage #1: 2-ethyl-hexanal oxime With hydrogenchloride; zinc In ethanol; water at 20℃; for 0.25h; Stage #2: With ammonia; sodium hydroxide In ethanol; water at 20℃; for 0.25h; | 5.513 g |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydroxylamine hydrochloride / ethanol / 0.67 h / 20 °C 2.1: hydrogenchloride; zinc / ethanol; water / 0.25 h / 20 °C 2.2: 0.25 h / 20 °C View Scheme |
2-Ethylhexyl alcohol
A
2-Ethylhexylamine
B
2-ethyl-N-(2-ethylhexyl)-1-hexanamine
Conditions | Yield |
---|---|
With chlorocyclopentadienylbis(triphenylphosphine)ruthenium(II); urea; diphenylphosphinopropane In diethylene glycol dimethyl ether at 160℃; for 12h; Autoclave; Inert atmosphere; |
Conditions | Yield |
---|---|
Stage #1: maleic anhydride; 2-Ethylhexylamine In toluene at 80℃; Stage #2: With 1,1,1,3,3,3-hexamethyl-disilazane; zinc dibromide In toluene at 80℃; for 2.5h; | 100% |
With chloroform Erwaermen des Reaktionsprodukts mit Natriumacetat und Acetanhydrid; |
2-Ethylhexylamine
methanesulfonyl chloride
N-(2-ethyl-hexyl)-methanesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 1h; | 100% |
2-Ethylhexylamine
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride
2,9-bis(2-ethylhexyl)anthra[2,1,9-def:6,5,10-d',e',f']diisoquinoline-1,3,8,10(2H,9H)-tetraone
Conditions | Yield |
---|---|
With 1H-imidazole; zinc diacetate at 160℃; for 5h; Inert atmosphere; | 99% |
With 1H-imidazole | 98% |
In N,N-dimethyl-formamide for 8h; Inert atmosphere; Reflux; | 97% |
2-Ethylhexylamine
Conditions | Yield |
---|---|
In toluene for 16h; Reflux; | 99% |
The CAS registry number of 2-Ethyl hexylamine is 104-75-6. Its EINECS registry number is 203-233-8. The IUPAC name is 2-ethylhexan-1-amine. In addition, the molecular formula is C8H19N and the molecular weight is 129.24. It is also called 1-amino-2-ethylhexane. What's more, it is a kind of colourless liquid and belongs to the classes of Industrial/Fine Chemicals; Butoctamide; Amines; C8; Nitrogen Compounds. It should be stored in sealed container, and put them in a cool and dry place.
Physical properties about this chemical are: (1)ACD/LogP: 2.87; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.23; (4)ACD/LogD (pH 7.4): -0.04; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.08; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 3.24 Å2; (13)Index of Refraction: 1.43; (14)Molar Refractivity: 42.6 cm3; (15)Molar Volume: 164.6 cm3; (16)Polarizability: 16.89 ×10-24cm3; (17)Surface Tension: 27.4 dyne/cm; (18)Density: 0.784 g/cm3; (19)Flash Point: 52.2 °C; (20)Enthalpy of Vaporization: 40.38 kJ/mol; (21)Boiling Point: 167.3 °C at 760 mmHg; (22)Vapour Pressure: 1.71 mmHg at 25°C.
Preparation of 2-Ethyl hexylamine: it can be prepared by 2-ethyl-hexan-1-ol. This reaction is a kind of substitution//mitsunobu reaction. It will need reagents sodium azide and Ph3P, and solvents CH2Cl2 and dimethylformamide. The reaction time is 5 hours at reaction temperature of 90 °C. The yield is about 92%.
Uses of 2-Ethyl hexylamine: it is used as raw materials for medicine, dyes, pesticides, sulfide accelerators, antioxidants, the flotation agents, emulsifiers, etc. In addition, it can be used to get 2-ethyl-hexanenitrile. This reaction will need reagent O2, catalyst RuHAP and solvent toluene. The reaction time is 24 hours at reaction temperature of 110 °C. The yield is about 99%.
When you are using this chemical, please be cautious about it as the following:
This chemical is flammable and can cause burns. And it is harmful by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show label where possible). What's more, you should keep away from sources of ignition and no smoking.
You can still convert the following datas into molecular structure:
(1)SMILES: NCC(CC)CCCC
(2)InChI: InChI=1/C8H19N/c1-3-5-6-8(4-2)7-9/h8H,3-7,9H2,1-2H3
(3)InChIKey: LTHNHFOGQMKPOV-UHFFFAOYAF
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD50 | skin | 600uL/kg (0.6mL/kg) | Union Carbide Data Sheet. Vol. 2/20/1963, | |
rat | LCLo | inhalation | 125ppm/4H (125ppm) | Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 343, 1949. | |
rat | LD50 | oral | 450mg/kg (450mg/kg) | Union Carbide Data Sheet. Vol. 2/20/1963, |