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3-Amino-2,2-dimethylpropionamide

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Name

3-Amino-2,2-dimethylpropionamide

EINECS 1806241-263-5
CAS No. 324763-51-1 Density 1.004 g/cm3
PSA 69.11000 LogP 0.85720
Solubility N/A Melting Point 74-75 °C
Formula C5H12N2O Boiling Point 270.7 °C at 760 mmHg
Molecular Weight 116.163 Flash Point 117.5 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 324763-51-1 (3-Amino-2,2-dimethylpropionamide) Hazard Symbols N/A
Synonyms

3-Amino-2,2-dimethylpropanamide;

Article Data 12

3-Amino-2,2-dimethylpropionamide Synthetic route

4300-97-4

3-Chloropivaloyl chloride

324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice
2: sodium methylate; ammonia / methanol / 50 h / 60 °C / Autoclave
View Scheme
Multi-step reaction with 4 steps
1.1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice
2.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube
2.2: 0.17 h / 0 - 20 °C
3.1: hydrogenchloride / 20 h / 20 °C
4.1: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
2843-17-6

3-bromo-2,2-dimethylpropionic acid

324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave
2: hydrogenchloride / 20 h / 20 °C
3: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
324763-51-1

aminopivalinamide

324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

acetic acid (1S,2S,4S)-2-azido-1-[(S)-2-(2-carbamoyl-2-methyl-propylcarbamoyl)-3-methyl-butyl]-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexyl ester

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 90℃; for 16h; After distillation of a part of Et3N over a period of 0.5 h further 8.5 h heating at 90 °ree;C;100%
324763-51-1

aminopivalinamide

1309922-72-2

(3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one

1607844-94-9

(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With propionic acid at 110℃; for 2h;95%
866030-35-5

tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate

324763-51-1

aminopivalinamide

173338-07-3

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate

Conditions
ConditionsYield
With 2-Ethylhexanoic acid In n-heptane at 60℃; Reagent/catalyst; Temperature; Solvent; Time;94%
With 2-Ethylhexanoic acid In n-heptane at 60℃; for 40h; Solvent; Reagent/catalyst;93%
With 2-Ethylhexanoic acid In n-heptane at 70℃; for 8h; Inert atmosphere;92%
324763-51-1

aminopivalinamide

1,1-dimethylethyl[(1S,3S)-3-[{4-methoxy-3-(3-methoxypropoxy)phenyl}methyl]-4-methyl-1-[tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamate

C35H61N3O8

Conditions
ConditionsYield
2-Ethylhexanoic acid In tetrahydrofuran at 100℃; for 6h; Product distribution / selectivity;93%
324763-51-1

aminopivalinamide

324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

Conditions
ConditionsYield
With propionic acid at 120℃; for 1.5h;87%
324763-51-1

aminopivalinamide

1236549-00-0

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester

1236549-06-6

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester

Conditions
ConditionsYield
With 2-Ethylhexanoic acid In di-isopropyl ether at 60℃; Solvent; Reagent/catalyst;86%
With 2-Ethylhexanoic acid In di-isopropyl ether at 60℃; Reagent/catalyst; Solvent;86%
With 2-hydroxypyridin; triethylamine In toluene for 16h; Reflux; Inert atmosphere;82%
324763-51-1

aminopivalinamide

C30H49NO7

C35H61N3O8

Conditions
ConditionsYield
With 2-Ethylhexanoic acid at 120℃; for 0.833333h;84%
142-08-5

2-hydroxypyridin

324763-51-1

aminopivalinamide

324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

324763-47-5

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With triethylamine79%

3-Amino-2,2-dimethylpropionamide Chemical Properties

Product Name: 3-Amino-2,2-dimethylpropionamide (CAS NO.324763-51-1)

Molecular Formula: C5H12N2O
Molecular Weight: 116.16g/mol
Mol File: 324763-51-1.mol
Melting Point: 74-75 °C
Boiling point: 270.7 °C at 760 mmHg
Flash Point: 117.5 °C
Density: 1.004 g/cm3
Surface Tension: 39.2 dyne/cm
Enthalpy of Vaporization: 50.88 kJ/mol
Vapour Pressure: 0.00675 mmHg at 25°C 

3-Amino-2,2-dimethylpropionamide Specification

 3-Amino-2,2-dimethylpropionamide , its CAS NO. is 324763-51-1, the synonyms are 2-(Aminomethyl)-2-methylpropanamide ; 3-Amino-2,2-dimethylpropionic acid amide .

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