Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	3-Methoxysalicylic acid	EINECS	212-888-9
CAS No.	877-22-5	Density	1.351 g/cm³
PSA	66.76000	LogP	1.09900
Solubility	N/A	Melting Point	147-150 °C(lit.)
Formula	C₈H₈O₄	Boiling Point	315.7 °C at 760 mmHg
Molecular Weight	168.149	Flash Point	131.7 °C
Transport Information	N/A	Appearance	beige powder
Safety	26-37/39-36	Risk Codes	36/37/38-20/21/22
Molecular Structure		Hazard Symbols	Xi,Xn
Synonyms	Salicylicacid, 3-methoxy- (4CI);m-Anisic acid, 2-hydroxy- (8CI);2-Hydroxy-3-methoxybenzoic acid;3-Methoxy-2-hydroxybenzoic acid;NSC 134533;NSC 408167;o-Vanillic acid;	Article Data	28

3-Methoxysalicylic acid Synthetic route

: 1521-38-6
2,3-dimethoxybenzoic acid

: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
With piperazine In N,N-dimethyl acetamide at 150℃; for 0.2h; Substitution;	94%
With hydrogen bromide

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
With potassium hydroxide; sodium tetrahydroborate; air; palladium on activated charcoal In methanol at 20℃; for 48h;	89%
With sodium chlorite; sodium dihydrogenphosphate; dimethyl sulfoxide In water Ambient temperature;	83%
With potassium hydroxide at 215℃;

: 4383-05-5
2-hydroxy-3-methoxybenzyl alcohol

: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate; 1% Pd/C; water; potassium hydroxide In methanol at 20℃; for 48h; In air;	89%

: 586-38-9
3-Methoxybenzoic acid

: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
With 2,2,6,6-tetramethylpiperidinyl-lithium; oxygen In tetrahydrofuran at 0 - 20℃;	54%
With [Fe(II)(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-ethylenediamine)(CH3CN)2](ClO4)2; dihydrogen peroxide In water; acetonitrile at 20℃; Inert atmosphere; regioselective reaction;	52 %Spectr.

: 124-38-9
carbon dioxide

: 90-05-1
2-methoxy-phenol

A: 121-34-6
3-methoxy-4-hydroxybenzoic acid

B: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
Stage #1: 2-methoxy-phenol With potassium hydroxide In water at 120℃; for 2h; Dean-Stark; Stage #2: carbon dioxide In 1-methyl-pyrrolidin-2-one at 118℃; for 2h; Temperature; Solvent; High pressure; regioselective reaction;	A 48% B n/a

: 2-acetoxy-1-methoxy-3-propyl-benzene

: 877-22-5
3-methoxysalicylic acid

: 196601-61-3
2-benzenesulfonyloxy-3-methoxy-benzoic acid

: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 109-72-8, 29786-93-4
n-butyllithium

: 60-29-7
diethyl ether

: 90-05-1
2-methoxy-phenol

A: 877-22-5
3-methoxysalicylic acid

B: 2169-28-0
2-methoxy-3-hydroxybenzoic acid

Conditions

Conditions	Yield
anschliessendes Behandeln mit CO2;

: 90-05-1
2-methoxy-phenol

: 877-22-5
3-methoxysalicylic acid

Conditions

Conditions	Yield
With potassium carbonate anschliessend Erhitzen mit Kohlendioxid, jeweils auf 180grad;

: 57544-05-5
8-methoxy-3-nitro-2-(4-methoxyphenyl)-2H-chromene

A: 877-22-5
3-methoxysalicylic acid

B: 91735-21-6
3-Hydroxy-8-methoxy-2-(4-methoxy-phenyl)-chromen-4-one

C: 100-09-4
4-methoxybenzoic acid

Conditions

Conditions	Yield
With dimethyl sulfoxide for 0.166667h;

3-Methoxysalicylic acid Chemical Properties

The Molecular formula of 2-HYDROXY-m-ANISIC ACID(877-22-5): C₈H₈O₄
The Molecular Weight of 2-HYDROXY-m-ANISIC ACID(877-22-5): 168.15
The Molecular Structure of 2-HYDROXY-m-ANISIC ACID(877-22-5):

EINECS: 212-888-9
Melting point: 147-150 °C(lit.)
Boiling Point: 315.7 °C at 760 mmHg
Flash Point: 131.7 °C
Index of Refraction: 1.585
Molar Refractivity: 41.74 cm³
Molar Volume: 124.3 cm³
Polarizability: 16.54 10^-24 cm³
Surface Tension: 56.5 dyne/cm
Density: 1.351 g/cm³
Enthalpy of Vaporization: 58.8 kJ/mol
Vapour Pressure: 0.000182 mmHg at 25°C
BRN: 2209642
IUPAC Name: 2-hydroxy-3-methoxybenzoic acid
Synonyms: GUAIACOL-3-CARBOXYLIC ACID;3-METHOXYSALICYLIC ACID;3-METHOXYSALICYLIC ACID MONOHYDRATE;3-METHOXY-2-HYDROXYBENZOIC ACID;2-hydroxy-3-methoxy-benzoicaci;2-hydroxy-m-anisicaci;3-hydroxy-m-anisicacid;acideorthovanillique;

3-Methoxysalicylic acid Toxicity Data With Reference

ipr-rat LD50:2056 mg/kg

COREAF Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences. 243 (1956),609.

3-Methoxysalicylic acid Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and fumes.
The Hazard Codes of 2-HYDROXY-m-ANISIC ACID(877-22-5):

Xi,Xn
The Risk Statements information of 2-HYDROXY-m-ANISIC ACID(877-22-5):
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-HYDROXY-m-ANISIC ACID(877-22-5):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
RTECS: BZ4840000

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 877-22-5