CAS No.144-83-2,Sulfapyridine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	144-83-2
Name:	Sulfapyridine
Article Data:	35

Formula:	C₁₁H₁₁N₃O₂S
Molecular Weight:	249.293
Synonyms:	Sulfanilamide,N1-2(1H)-pyridylidene- (6CI,7CI);Sulfanilamide, N1-2-pyridyl- (8CI);Sulfanilamide, N4-2-pyridyl- (4CI);2-Sulfanilamidopyridine;2-Sulfapyridine;4-Amino-N-2-pyridinylbenzenesulfonamide;4-[(2-Pyridylamino)sulfonyl]aniline;A-499;Adiplon;Coccoclase;Dagenan;Eubasin;Eubasinum;Haptocil;M and B 693;N-(2-Pyridyl)-4-aminobenzenesulfonamide;N1-2-Pyridylsulfanilamide;NSC 41791;NSC 4753;Piridazol;Pirodazole;Plurazol;Pyriamid;Pyridazol;Relbapiridina;Ronin;Streptosilpyridine;Sulfapyridine;Sulfidin;Sulphapyridine;Thioseptal;Trianon;
EINECS:	205-642-7
Density:	1.432 g/cm³
Melting Point:	191-193 °C
Boiling Point:	473.5 °C at 760 mmHg
Flash Point:	240.2 °C
Solubility:	<0.1 g/100 mL at 22 °C in water
Appearance:	white or yellowish-white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	22-24/25-36-26
PSA:	93.46000
LogP:	3.19960

Synthetic route

: 1028-11-1
4-nitro-N-(pyridin-2-yl)benzenesulfonamide

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With iron; ammonium chloride In methanol at 80℃; for 3h; Temperature; Solvent;	81%
With iron; acetic acid
With iron; ammonium chloride In methanol; water at 70℃; for 4h;
With sodium hydroxide; water; iron(II) sulfate

: 504-29-0
2-aminopyridine

: 98-62-4
4-aminobenzenesulfonyl fluoride

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With N,N-dimethyl-aniline at 180℃;

: 504-29-0
2-aminopyridine

: 107145-69-7
N-dichlorophosphoryl-sulfanilyl chloride

: 144-83-2
sulphapyridine

: 504-29-0
2-aminopyridine

: 101570-35-8
3-(4-acetylamino-benzenesulfonyl)-2-benzenesulfonylimino-2,3-dihydro-thiazole

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With pyridine; sodium hydroxide; water

: 504-29-0
2-aminopyridine

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
at 140℃;
Stage #1: 2-aminopyridine; p-acetylaminobenzenesulfonyl chloride With pyridine In tetrahydrofuran at 20℃; for 6h; Stage #2: With sodium hydroxide for 2h; Reflux;

: 109-04-6
2-bromo-pyridine

: 63-74-1
sulfanilamide

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With copper; potassium carbonate at 180℃;

: 5029-67-4
2-iodopyridine

: 63-74-1
sulfanilamide

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With copper; potassium carbonate at 150℃;

: 1213-38-3
4-chloro-N-pyridin-2-yl-benzenesulfonamide

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With ammonia; water; copper; copper dichloride at 150 - 160℃;
With ammonia; water; copper(l) chloride at 150 - 175℃;

: 99360-04-0
4-(butanoylamino)benzenesulfonyl chloride

: 40825-17-0
Natrium-Verbindung des [2]Pyridylamins

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With sodium hydroxide; water; Petroleum ether

: 19077-98-6
N-acetylsulfapyridine

: 144-83-2
sulphapyridine

Conditions

Conditions	Yield
With sodium hydroxide; water
With calcium hydroxide; water
With hydrogenchloride; water at 60℃;

Raw Materials

599-79-1

121-60-8

109-04-6

5029-67-4

98-62-4

98-74-8

504-29-0

121-61-9

Downstream Products

599-79-1

722-27-0

58944-05-1

6325-93-5

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

Sulfapyridine, with the CAS registry number 144-83-2, it is also named as 2-(p-Aminobenzenesulphonamido)pyridine. The product's categories are Aromatics Compounds; Aromatics; Sulfur & Selenium Compounds. It is white or yellowish-white crystalline powder which is stable, combustible, potentially toxic and incompatible with strong oxidizing agents. What's more, this chemical can be obtained by condensation and hydrolysis of 2-aminopyridine. Additionally, it should be stored at the temperature of 2-8 °C.

Physical properties about Sulfapyridine are: (1)ACD/LogP: 0.469; (2)ACD/LogD (pH 5.5): 0.47; (3)ACD/LogD (pH 7.4): 0.41; (4)ACD/BCF (pH 5.5): 1.34; (5)ACD/BCF (pH 7.4): 1.16; (6)ACD/KOC (pH 5.5): 42.77; (7)ACD/KOC (pH 7.4): 37.14; (8)#H bond acceptors: 5; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.674; (12)Molar Refractivity: 65.348 cm³; (13)Molar Volume: 174.056 cm³; (14)Polarizability: 25.906 10-24cm³; (15)Surface Tension: 73.056999206543 dyne/cm; (16)Density: 1.432 g/cm³; (17)Flash Point: 240.188 °C; (18)Enthalpy of Vaporization: 73.669 kJ/mol; (19)Boiling Point: 473.538 °C at 760 mmHg

Uses of Sulfapyridine: It is antibacterial which is used to treat certain skin diseases. But it is not prescribed for treatment in humans any more. And it is also used as pharmaceutical intermediate.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin, so people should not breathe dust and avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(Nc1ncccc1)c2ccc(N)cc2
2. InChI:InChI=1/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 454, 1939.
mouse	LD50	intraperitoneal	1150mg/kg (1150mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archivum Immunologiae et Therapiae Experimentalis. Vol. 16, Pg. 804, 1968.
mouse	LD50	oral	16600mg/kg (16600mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TREMOR	Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938.
rabbit	LDLo	oral	20gm/kg (20000mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 62, Pg. 281, 1939.
rat	LD50	intravenous	800mg/kg (800mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat	LD50	oral	15800mg/kg (15800mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE	Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938.