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Name	4-Dimethylaminobenzoic acid	EINECS	210-615-8
CAS No.	619-84-1	Density	1.18 g/cm³
PSA	40.54000	LogP	1.45080
Solubility	Insoluble in water.	Melting Point	241-243 °C (dec.)(lit.)
Formula	C₉H₁₁NO₂	Boiling Point	315.8 °C at 760 mmHg
Molecular Weight	165.192	Flash Point	144.8 °C
Transport Information	N/A	Appearance	light grey powder
Safety	26-37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	N,N-Dimethyl-4-aminobenzoic acid;N,N-Dimethyl-p-aminobenzoic acid;p-Dimethylamino benzoic acid;p-N,N-(Dimethylamino)benzoic acid;4-Dimethylaminobenzoic acid;Benzoic acid, 4-(dimethylamino)-;Benzoic acid, p-(dimethylamino)-;NSC 16596;	Article Data	141

4-Dimethylaminobenzoic acid Synthetic route

: 1703-46-4
N,N-dimethyl-4-hydroxymethylaniline

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With silica-supported Jones reagent In dichloromethane for 0.035h;	99.6%
With oxygen In acetonitrile at 20℃; for 7h; Catalytic behavior;	96%
With tert.-butylhydroperoxide; copper(ll) bromide In water; acetonitrile at 20℃; for 22.5h; Inert atmosphere; chemoselective reaction;	90%

: 66379-84-8
2,2,2-trichloro-1-[4-(dimethylamino)phenyl]ethan-1-ol

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In methanol for 10h;	98%

: 5925-53-1
4-<4-(Dimethylamino)thiobenzoyl>morpholine

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 0.0166667h; microwave irradiation;	97%

: 22636-68-6
allyl 4-(dimethylamino)benzoate

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide; mineral oil at 25℃; for 4h; Inert atmosphere;	97%
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 60℃; for 3h; Inert atmosphere;	86%

: 100-10-7
4-dimethylamino-benzaldehyde

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With Co4HP2Mo15V3O62; N-(4-sulfonic acid)butyl triethylammonium tetrafluoroborate; dihydrogen peroxide In water at 20℃; for 3h; Green chemistry;	95%
With tert.-butylhydroperoxide; copper(ll) bromide In water; acetonitrile at 20℃; for 4.5h; Inert atmosphere; chemoselective reaction;	92%
With sodium chlorite In acetonitrile 1.) 10 deg C, 2 h, 2.) RT, 3 h;	89%

: 124-38-9
carbon dioxide

: 586-77-6
4-bromo-N,N-dimethylaniline

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With C26H30B10Cl2P2Pd In toluene at 50℃; under 760.051 Torr; for 8h;	90%
With [2,2]bipyridinyl; lithium chloride; cobalt(II) iodide; zinc In N,N-dimethyl-formamide; acetonitrile at 40℃; under 760.051 Torr; for 14h; Sealed tube;	61%
With diethylzinc; palladium diacetate; tert-butyl XPhos In hexanes; N,N-dimethyl acetamide at 40℃; under 7600.51 Torr; Automated synthesizer;	40%
Stage #1: 4-bromo-N,N-dimethylaniline With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 0.5h; Stage #2: With [2,2]bipyridinyl; (-)-menthol In tetrahydrofuran; pentane Inert atmosphere; Stage #3: carbon dioxide In tetrahydrofuran; pentane at 20℃; under 5171.62 Torr; for 0.0166667h; Flow reactor;

: 124-38-9
carbon dioxide

: 95752-87-7
5,5-dimethyl-2-(4-(N,N-dimethylamino)phenyl)-1,3,2-dioxaborinane

A: 1202-25-1
methyl 4-(N,N-dimethylamino)benzoate

B: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;	A 87% B n/a

: 124-38-9
carbon dioxide

: 95752-87-7
5,5-dimethyl-2-(4-(N,N-dimethylamino)phenyl)-1,3,2-dioxaborinane

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-(N,N-dimethylamino)phenyl)-1,3,2-dioxaborinane With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃;	84%

: 124-38-9
carbon dioxide

: 10541-83-0
N-methyl-p-aminobenzoic acid

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
With phenylsilane In N,N-dimethyl acetamide at 60℃; for 4h; Reagent/catalyst; Sealed tube;	84%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 28611-39-4
4-(dimethylamino)benzene-boronic acid

: 619-84-1
p-N,N-dimethylaminobenzoic acid

Conditions

Conditions	Yield
Stage #1: tert-butylisonitrile; 4-(dimethylamino)benzene-boronic acid With copper diacetate; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 24h; Molecular sieve; Sealed tube; Stage #2: With water In N,N-dimethyl-formamide Molecular sieve; Sealed tube;	83%

4-Dimethylaminobenzoic acid Chemical Properties

Chemical Name: 4-Dimethylaminobenzoic acid
IUPAC Name: 4-(Dimethylamino)benzoic acid
Synonyms of 4-(Dimethylamino)benzoic acid (CAS NO.619-84-1): EINECS 210-615-8 ; N,N-Dimethyl-4-aminobenzoic acid ; N,N-Dimethyl-p-aminobenzoic acid ; NSC 16596 ; p-Dimethylamino benzoic acid ; p-N,N-(Dimethylamino)benzoic acid ; 4-Dimethylaminobenzoic acid ; Benzoic acid, 4-(dimethylamino)- ; Benzoic acid, p-(dimethylamino)-
CAS NO: 619-84-1
Molecular Formula of 4-(Dimethylamino)benzoic acid (CAS NO.619-84-1): C₉H₁₁NO₂
Molecular Weight: 165.1891
Molecular Structure:

Melting Point: 241-243 °C
ProductCategories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts ; Organic acids ; Absolute Configuration Determination (Exciton Chirality CD Method) ; Analytical Chemistry ; Enantiomer Excess & Absolute Configuration Determination ; Exciton Chirality CD Method (for Hydroxyl Groups) ; Aromatic Amino Acids ; Peptide Synthesis ; Unnatural Amino Acid Derivatives
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.594
Molar Refractivity: 47.49 cm³
Molar Volume: 139.9 cm³
Surface Tension: 49.6 dyne/cm
Density of 4-(Dimethylamino)benzoic acid (CAS NO.619-84-1): 1.18 g/cm³
Flash Point: 144.8 °C
Enthalpy of Vaporization: 58.81 kJ/mol
Boiling Point: 315.8 °C at 760 mmHg
Vapour Pressure: 0.00018 mmHg at 25°C
Appearance: light grey powder
Stability: Stable but incompatible with strong oxidizing agents.

4-Dimethylaminobenzoic acid Uses

An important intermediate used as photosensitizer, paints and dyes

4-Dimethylaminobenzoic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04362,

4-Dimethylaminobenzoic acid Consensus Reports

Reported in EPA TSCA Inventory.

4-Dimethylaminobenzoic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: DG8735000
HS Code: 29224995
Poison by intravenous route. When heated to decomposition it emits toxic vapors of NO_x.

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