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4-Methoxy-2-methylaniline
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  • Name 4-Methoxy-2-methylaniline
  • EINECS203-036-7
  • CAS No. 102-50-1
  • Density1.065 g/cm3
  • PSA35.25000
  • LogP2.16700
  • Solubilityinsoluble,
  • Melting Point13-14 °C(lit.)
  • FormulaC8H11NO
  • Boiling Point249.4 °C at 760 mmHg
  • Molecular Weight137.181
  • Flash Point113.5 °C
  • Transport InformationN/A
  • Appearancebrick red crystals or liquid
  • Safety26-36/37/39-53-45
  • Risk Codes36/37/38-40-45
  • Molecular Structure
    Molecular Structure of 102-50-1 (2-Methyl-4-methoxybenzenamine)
  • Hazard SymbolsIrritantXi,HarmfulXn,ToxicT
  • SynonymsIrritantXi,HarmfulXn,ToxicT
  • Article Data32

4-Methoxy-2-methylaniline Synthetic route

5367-32-8

5-methoxy-2-nitrotoluene

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In isopropyl alcohol under 2327.2 Torr;98.5%
With sodium formate In ethanol at 85℃; for 1h;87%
With tetrahydroxydiboron; water at 80℃; for 8h;80%
208399-66-0

4-methoxy-2-methylphenyl boronic acid

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;89%
27060-75-9

4-bromo-3-methylanisole

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With ammonium sulfate; (R)-(-)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; bis(tri-ortho-tolylphosphine)palladium(0); sodium t-butanolate In 1,4-dioxane at 100℃; for 6h; Inert atmosphere; Glovebox;80%
With ammonium hydroxide; copper(l) iodide; potassium carbonate; 4R-4-hydroxyproline In dimethyl sulfoxide at 70℃; for 36h;77%
154876-10-5

1-(4-methoxy-2-methylphenyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With acetic acid; zinc for 0.75h; Ambient temperature;76%
13334-71-9

1-chloro-4-methoxy-2-methylbenzene

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(2,4,6-trimethoxyphenyl)oxalamide In water; dimethyl sulfoxide at 120℃; for 48h; Inert atmosphere;64%
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate In 1,4-dioxane at 65℃; for 24h; Inert atmosphere; chemoselective reaction;52%
31601-41-9

N-(4-methoxy-2-methylphenyl)acetamide

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With hydrogenchloride
67-56-1

methanol

611-22-3

N-(o-tolyl)hydroxylamine

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With sulfuric acid at 25℃; durch wochenlange Einw.;
100-17-4

para-methoxynitrobenzene

676-58-4

methylmagnesium chloride

A

5961-59-1

N-methyl-N-(4-methoxyphenyl)amine

B

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With lithium aluminium tetrahydride; palladium on activated charcoal 1) THF, 20 min, -30 deg C, 2) 20 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
4-methoxy-2-methyl-acetophenone oxime

4-methoxy-2-methyl-acetophenone oxime

102-50-1

2-methyl-4-methoxyaniline

Conditions
ConditionsYield
With hydrogenchloride
7647-01-0

hydrogenchloride

75112-71-9

1-(4-methoxy-2-methyl-phenyl)-ethanone oxime

102-50-1

2-methyl-4-methoxyaniline

4-Methoxy-2-methylaniline Chemical Properties

MF: C8H11NO
MW: 137.18
EINECS: 203-036-7
2-METHYL-p-ANISIDINE(102-50-1),Its melting point is about  13-14 °C(lit.);boiling point is  248-249 °C(lit.);density is 1.065 g/mL at 25 °C(lit.) .Following is the molecular structure of 2-METHYL-p-ANISIDINE(102-50-1):

4-Methoxy-2-methylaniline Uses

2-METHYL-p-ANISIDINE(102-50-1) can be used as medicine and dye intermediates.

4-Methoxy-2-methylaniline Toxicity Data With Reference

1.   

otr-rat:emb 51,500 ng/plate

   JJATDK    JAT, Journal of Applied Toxicology. 1 (1981),190.

RTECS  :BZ6730000

4-Methoxy-2-methylaniline Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 27 ,1982,p. 91.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (gavage); Clear Evidence: rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-105 ,1978. ; (gavage); Inadequate Studies: mouse NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-105 ,1978. . Reported in EPA TSCA Inventory.

4-Methoxy-2-methylaniline Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Other safty informations about 2-METHYL-p-ANISIDINE(102-50-1):
Hazard Codes:  Xi,Xn,T (Irritant;Harmful;Toxic)
Risk Statements :
R36/37/38:Irritating to eyes, respiratory system and skin
R40:Limited evidence of a carcinogenic effect
R45 :May cause cancer
Safety Statements :
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection
S53:Avoid exposure - obtain special instruction before use 
S45 :In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR : 2810
WGK Germany : 3
 

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