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Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite In acetonitrile at 35℃; pH 6.7; | 100% |
With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; water; acetonitrile at 35℃; pH=6.7; Reagent/catalyst; Green chemistry; | 100% |
With periodic acid; pyridinium chlorochromate In acetonitrile | 99% |
4-Methoxymandelic acid
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid at 60℃; for 2h; Reagent/catalyst; Temperature; | 99.1% |
2-(4-methoxyphenyl)-1-(pyrrolidin-1-yl)ethan-1-one
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 36h; Heating; | 99% |
Conditions | Yield |
---|---|
Stage #1: 4-methoxysalicylaldehyde; ethylene glycol With sodium nitrate; aluminum isopropoxide at 47℃; for 1.5h; Stage #2: With cobalt(II) chloride at 56℃; for 3h; Temperature; | 98.9% |
N-[(E)-1-Cyano-2-(4-methoxy-phenyl)-vinyl]-4,N-dimethyl-benzamide
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran for 6h; Heating; | 96% |
Conditions | Yield |
---|---|
Stage #1: butan-1-ol With cobalt(II) sulfate at 80℃; under 3750.38 Torr; for 4h; Autoclave; Stage #2: p-methoxybenzyl chloride With sodium hydroxide In water at 80℃; under 3750.38 Torr; for 24h; Concentration; Pressure; Temperature; Autoclave; | 93.6% |
4-methoxy-phenyl acetic acid methyl ester
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide for 2h; Heating; | 93% |
With sodium hydroxide In methanol for 4h; Ambient temperature; | 92% |
With potassium carbonate; thiophenol In 1-methyl-pyrrolidin-2-one at 190℃; for 0.166667h; Substitution; | 80% |
(4-methoxy-phenyl)-acetic acid-(4-nitro-benzyl ester)
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
With zinc In tetrahydrofuran for 3.5h; Ambient temperature; | 93% |
92.6% |
ethyl p-methoxyphenylacetate
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 4h; Ambient temperature; | 92% |
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14; | 91% |
Stage #1: ethyl p-methoxyphenylacetate With water; sodium hydroxide In methanol at 20℃; for 1h; Stage #2: With hydrogenchloride In water | 67% |
With potassium hydroxide |
2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol
4-Methoxyphenylacetic acid
Conditions | Yield |
---|---|
Stage #1: 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol With sodium tetrahydroborate; diphenyl diselenide In ethanol Inert atmosphere; Stage #2: With sodium hydroxide In ethanol at 40℃; Inert atmosphere; | 92% |
IUPAC Name:2-(4-methoxyphenyl)acetic acid
Molecular Formula:C9H10O3
Molecular Weight:166.173900 g/mol
Appearance:White flaky crystal
Melting Point:84-86 °C(lit.)
Boiling Point:140 °C 3 mm Hg(lit.)
Flash Point:193°C
Solubility:ethanol and ether
Water Solubility:6 g/L (20°C)
BRN:1101737
CAS DataBase Reference:104-01-8(CAS DataBase Reference)
NIST Chemistry Reference:104-01-8(NIST)
EPA Substance Registry System:104-01-8(EPA Substance)
Synonyms of p-METHOXYPHENYLACETIC ACID(104-01-8):
ASISCHEM D13364;LABOTEST-BB LT00848110;HOMOANISIC ACID;HOMO-P-ANISIC ACID;4-METHOXYPHENYLACETIC ACID;P-METHOXY-A-CARBOXYTOLUENE;P-METHOXYPHENYLACETIC ACID;RARECHEM AL BO 0133
Categories of p-METHOXYPHENYLACETIC ACID(104-01-8):
Aromatic Phenylacetic Acids and Derivatives;pharmacetical
p-METHOXYPHENYLACETIC ACID(104-01-8) is used in organic synthesis, especially used as a intermediate of puerarin.
1. | orl-rat LD50:1550 mg/kg | FCTXAV Food and Cosmetics Toxicology. 14 (1976),659. | ||
2. | ipr-mus LD50:504 mg/kg | JMCMAR Journal of Medicinal Chemistry. 20 (1977),709. |
Safety Information of p-METHOXYPHENYLACETIC ACID(104-01-8):
Hazard Codes:Xn,Xi
Risk Statements:22-36/37/38-20/21/22
22:Harmful if swallowed
36/37/38:Irritating to eyes, respiratory system and skin
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
WGK Germany:3
RTECS:AI8960000
Hazard Note:Irritant
HS Code:29189090
Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.