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5-Aminolevulinic acid

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Name

5-Aminolevulinic acid

EINECS 203-414-1
CAS No. 106-60-5 Density 1.231 g/cm3
PSA 80.39000 LogP 0.07930
Solubility N/A Melting Point 118-119 °C
Formula C5H9NO Boiling Point 298.4 °C at 760 mmHg
Molecular Weight 131.131 Flash Point 134.3 °C
Transport Information N/A Appearance White crystalline powder
Safety Risk Codes R10; R36/37/38; R20/21/22
Molecular Structure Molecular Structure of 106-60-5 (Pentanoic acid,5-amino-4-oxo-) Hazard Symbols Xi
Synonyms

Levulinicacid, 5-amino- (8CI);5-Amino-4-oxopentanoic acid;Aladerm;Alasens;Aminolevulinic acid;Kerastick;Levulan;d-Aminolevulinic acid;

Article Data 35

5-Aminolevulinic acid Specification

The CAS registry number of Pentanoic acid,5-amino-4-oxo- is 106-60-5. The IUPAC name is 5-amino-4-oxopentanoic acid. Its EINECS registry number is 203-414-1. In addition, the molecular formula is C5H9NO and the molecular weight is 131.13. It belongs to the class of Photodynamic Therapy of Cancer. What's more, it can be get through the microorganism fermentatio.

Physical properties about this chemical are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 4; (6)#H bond donors: 3; (7)#Freely Rotating Bonds: 5; (8)Polar Surface Area: 80.39 Å2; (9)Index of Refraction: 1.482; (10)Molar Refractivity: 30.343 cm3; (11)Molar Volume: 106.492 cm3; (12)Polarizability: 12.029 ×10-24cm3; (13)Surface Tension: 52.733 dyne/cm; (14)Density: 1.231 g/cm3; (15)Flash Point: 134.264 °C; (16)Enthalpy of Vaporization: 59.215 kJ/mol; (17)Boiling Point: 298.394 °C at 760 mmHg; (18)Vapour Pressure: 0 mmHg at 25°C.

Uses of Pentanoic acid,5-amino-4-oxo-: it is a kind of photodynamic therapy drugs which can treat the light of the ossification disease and basal cell tumor. And it can react with pentane-2,4-dione to get 3-(4-acetyl-5-methyl-pyrrol-3-yl)-propionic acid and 4-(3,5-dimethyl-pyrrol-2-yl)-4-oxo-butyric acid. This reaction will need reagent acetate buffer and solvent H2O. The reaction time is 30 minutes by heating. The yield is about 62%.

Pentanoic acid,5-amino-4-oxo can react with pentane-2,4-dione to get 3-(4-acetyl-5-methyl-pyrrol-3-yl)-propionic acid and 4-(3,5-dimethyl-pyrrol-2-yl)-4-oxo-butyric acid.

You can still convert the following datas into molecular structure:
(1)SMILES: C(CC(=O)O)C(=O)CN
(2)InChI: InChI=1/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
(3)InChIKey: ZGXJTSGNIOSYLO-UHFFFAOYAL

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