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Cas Database |
| Name |
5-Ethoxy-4-methyloxazole |
EINECS | N/A |
| CAS No. | 5006-20-2 | Density | 1.04 g/cm3 |
| PSA | 35.26000 | LogP | 1.38170 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C6H9NO2 | Boiling Point | 164.5 °C at 760 mmHg |
| Molecular Weight | 127.143 | Flash Point | 53.3 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26-36/37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
4-Methyl-5-ethoxyoxazole; |
Article Data | 28 |
5-Ethoxy-4-methyloxazole Synthetic route
- 23429-05-2
4-methyl-5-ethoxy-2-carboxyoxazole
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| With hydrogenchloride In chloroform at 50℃; pH=2.5; | 94.8% |
| at 90℃; for 1h; Temperature; |
- 23429-04-1
4-methyl-5-ethoxy-2-oxazole carboxylate ethyl ester
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| Stage #1: 4-methyl-5-ethoxy-2-oxazole carboxylate ethyl ester With sodium hydroxide Stage #2: With hydrogenchloride | 89.9% |
| With toluene-4-sulfonic acid; acetic acid In toluene at 90℃; for 3h; Solvent; Temperature; Reagent/catalyst; | 93.7 %Chromat. |
| Stage #1: 4-methyl-5-ethoxy-2-oxazole carboxylate ethyl ester With sodium hydroxide In water Stage #2: With hydrogenchloride In water at 60 - 62℃; pH=2.5; |
| Conditions | Yield |
|---|---|
| With boron trifluoride diethyl etherate; magnesium oxide In dichloromethane at 120℃; for 8h; Reagent/catalyst; Temperature; Solvent; Sealed tube; | 71% |
| With phosphorus pentoxide; magnesium oxide In chloroform for 20h; Heating; | 50% |
| With phosphorus pentoxide In dichloromethane for 48h; Reflux; | 50% |
- 17344-99-9
AlaOEt
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 1.5 h / Reflux 2: phosphorus pentoxide; magnesium oxide / chloroform / 20.5 h / 20 °C / Inert atmosphere; Reflux View Scheme | |
| Multi-step reaction with 2 steps 1: 2 h / 160 °C 2: 48 h / Reflux View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 1 h / 76 °C / Inert atmosphere 2: 2 h / 150 °C / Inert atmosphere View Scheme |
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| at 150℃; for 2h; Temperature; Inert atmosphere; | 30.5 g |
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| at 130℃; for 2h; Temperature; Inert atmosphere; | 28.5 g |
- 23460-73-3
N-ethoxyoxalylalanine ethyl ester
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: triethylamine; trichlorophosphate / toluene / 3 h / 55 - 110 °C 2: water; sodium hydroxide / 5 h / 50 - 55 °C / pH 14 3: 1 h / 90 °C View Scheme | |
| With triethylamine; Triphenylphosphine oxide; trichloromethyl chloroformate In dichloromethane at 0 - 50℃; for 2.5h; Reagent/catalyst; Solvent; | 97 %Chromat. |
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid; acetic acid In 1,4-dioxane at 90℃; for 2h; Reagent/catalyst; Solvent; | 93.7 %Chromat. |
- 5006-20-2
5-ethoxy-4-methyl-oxazole
| Conditions | Yield |
|---|---|
| With sodium acetate; benzoic acid In acetonitrile at 90℃; for 2h; | 40.2 %Chromat. |
5-Ethoxy-4-methyloxazole Specification
The 5-Ethoxy-4-methyloxazole with the cas number 5006-20-2, is also called 4-Methyl-5-ethoxyoxazole. 5-Ethoxy-4-methyloxazole belongs to the following product categories: Oxazole and Isoxazole. Raw material of 5-Ethoxy-4-methyloxazole are as the following: (1)Chloroform; (2)Phosphorus pentoxide; (3)Formamide; (4)L-Alanine; (5)Ethyl 2-aminopropanoate hydrochloride
Properties of 5-Ethoxy-4-methyloxazole are as the following: (1)H bond acceptors: 3 ; (2)H bond donors: 0 ; (3)Freely Rotating Bonds: ; (4)2 Polar Surface Area: 35.26 Å ; (5)Index of Refraction: 1.448 ; (6)Molar Refractivity: 32.78 cm3 ; (7)Molar Volume: 122.2 cm3 ; (8) Polarizability: 12.99 ×10-24cm3 ; (9)Surface Tension: 31.4 dyne/cm ; (10)Density: 1.04 g/cm3 ; (11)Flash Point: 53.3 °C ; (12)Enthalpy of Vaporization: 38.45 kJ/mol ; (13)Boiling Point: 164.5 °C at 760 mmHg ; (14)Vapour Pressure: 2.58 mmHg at 25°C
You can still convert the following datas into molecular structure :
1. SMILES: O(c1ocnc1C)CC
2. SMILES: InChI=1/C6H9NO2/c1-3-8-6-5(2)7-4-9-6/h4H,3H2,1-2H3
The 5-Ethoxy-4-methyloxazole can react with methanol and 3c-chloro-acrylic acid to generate 2-methyl-3-hydroxy-4-carboxy-6-methoxypyridine under ambient temperature, with productivity 33 % .
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The 5-Ethoxy-4-methyloxazole can also react with phenylpropynoic acid ethyl ester to generate 2-ethoxy-4-phenyl-furan-3-carboxylic acid ethyl ester in toluene for 3 hour heating. Productivity is around 90 % .
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