Basic information
- Name:
Azelnidipine
- CAS No.:
123524-52-7
- Molecular Structure:
- Formula:
- C33H34N4O6
- Molecular Weight:
- 582.65
- Synonyms:
- Calblock;CS 905;3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-;3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Calblock (TN);(1-benzhydrylazetidin-3-yl) propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Azelidipine;2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxy lic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(methylethyl) ester;
- Density:
- 1.33 g/cm3
- Melting Point:
- 120-126 ºC
- Boiling Point:
- 709.3 ºC at 760 mmHg
- Flash Point:
- 382.8 ºC
- Appearance:
- light yellowish powder
- Hazard Symbols:
Xn- Risk Codes:
- 22-41
- Safety Description:
- 26-39 Details
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
Molecular Structure:
.png)
Molecular Formula: C33H34N4O6
Molecular Weight: 582.6463
IUPAC Name: 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms of Azelnidipine (CAS NO.123524-52-7): 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate ; Azelnidipine ; CCRIS 8650 ; CS 905 ; UNII-PV23P19YUG ; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)- ; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)- ; 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
CAS NO: 123524-52-7
Classification Code: Drug / Therapeutic Agent
Melting Point: 120-126°C
Index of Refraction: 1.658
Molar Refractivity: 161.27 cm3
Molar Volume: 437.4 cm3
Surface Tension: 64.1 dyne/cm
Density: 1.33 g/cm3
Flash Point: 382.8 °C
Enthalpy of Vaporization: 103.74 kJ/mol
Boiling Point: 709.3 °C at 760 mmHg
Vapour Pressure: 5.74E-20 mmHg at 25°C
Uses
Azelnidipine (CAS NO.123524-52-7) (INN; marketed under the brand name Calblock) is a dihydropyridine CALCIUM channel blocker.Unlike Nicardipine, Azelnidipine has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 800mg/kg (800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | oral | 785mg/kg (785mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | oral | 1267mg/kg (1267mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA MUSCULOSKELETAL: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
Safety Profile
Hazard Codes Azelnidipine (CAS NO.123524-52-7): Xn
Risk Statements: 22-41
Safety Statements: 26-39
RTECS: US7968332
Specification
Legal status : Prescription only
Routes :Oral
