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Name |
Bromopride |
EINECS | N/A |
CAS No. | 4093-35-0 | Density | 1.313g/cm3 |
PSA | 67.59000 | LogP | 3.08360 |
Solubility | N/A | Melting Point |
148-150?C |
Formula | C14H22 Br N3 O2 | Boiling Point | 435.8°Cat760mmHg |
Molecular Weight | 344.252 | Flash Point | 217.3°C |
Transport Information | N/A | Appearance | N/A |
Safety | Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Br−. | Risk Codes | 20/21/22 |
Molecular Structure | Hazard Symbols | ||
Synonyms |
o-Anisamide,4-amino-5-bromo-N-[2-(diethylamino)ethyl]- (7CI,8CI); 2-Methoxy-4-amino-5-bromo-N,N-diethylaminoethylbenzamide;Bromopride; Emepride; Emoril;N-Diethylaminoethyl-2-methoxy-4-amino-5-bromobenzamide; Viadil |
Article Data | 14 |
carbon monoxide
2-bromo-4-iodo-5-methoxyaniline
N,N-diethylethylenediamine
bromopride
Conditions | Yield |
---|---|
With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 80℃; Inert atmosphere; Sealed chamber; | 74.7 mg |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride; iron / ethanol; water / 3 h / Reflux 2: tetramethylammonium dichloroiodate(I) / ethyl acetate / 96 h 3: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme |
2-bromo-5-methoxyaniline
bromopride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetramethylammonium dichloroiodate(I) / ethyl acetate / 96 h 2: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid; acetic acid; sodium nitrite / water / 15 - 20 °C 1.2: 20 - 80 °C 2.1: hydrogenchloride; iron / ethanol; water / 3 h / Reflux 3.1: tetramethylammonium dichloroiodate(I) / ethyl acetate / 96 h 4.1: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme |
bromopride
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethanol Ambient temperature; | 11% |
bromopride
Conditions | Yield |
---|---|
Stage #1: bromopride With trifluoroacetic acid; thallium(III) trifluoroacetate at 20℃; for 0.5h; thallation; Stage #2: With trifluoroacetic acid; sodium iodide at 20℃; for 5h; Iodination; Further stages.; |
bromopride
Conditions | Yield |
---|---|
Stage #1: bromopride With trifluoroacetic acid; thallium(III) trifluoroacetate for 0.166667h; thallation; Stage #2: With [131I]-sodium iodide; trifluoroacetic acid for 0.0833333h; Iodination; Further stages.; |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium dodecyl-sulfate In water Reagent/catalyst; Flow reactor; |
IUPAC Name: 4-amino-5-bromo-N-(2-diethylaminoethyl)-2-methoxybenzamide
Synonyms: 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-2-methoxy-benzamid ; 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-o-anisamid ; Artomey ; Bromoprida ; Emepride
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula of Valopride (CAS NO. 4093-35-0 ) : C14H22BrN3O2
Structure of Valopride (CAS NO.4093-35-0 ) :
EINECS: 223-842-2
Molecular Weight: 344.25 g/mol
Surface Tension: 44.8 dyne/cm
Index of Refraction: 1.565
Melting point : 149°C
Storage temp: 2-8°C
Density: 1.313 g/cm3
Flash Point: 217.3 °C
Boiling Point: 435.8 °C at 760 mmHg
Vapour Pressure: 8.53E-08 mmHg at 25°C
Enthalpy of Vaporization: 69.21 kJ/mol
Appearance: a solid
Valopride (CAS NO.4093-35-0 ) was used as an antiemetic.
1. | orl-rat LD50:545 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),516. | ||
2. | ipr-rat LD50:125 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),516. | ||
3. | orl-mus LD50:310 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),516. | ||
4. | ipr-mus LD50:105 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),516. |
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Br−.
Hazard Codes: Xn
Risk Statements: 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: BZ3280000
Classification Code of Valopride (CAS NO.4093-35-0 ) : Drug / Therapeutic Agent;Reproductive Effect;Tumor data