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Cas Database

Name	Bombesin	EINECS	N/A
CAS No.	31362-50-2	Density	1.5g/cm³
PSA	711.43000	LogP	2.59880
Solubility	0.05 M acetic acid: 20 mg/mL, clear, colorless	Melting Point	N/A
Formula	C71H110 N24 O18 S	Boiling Point	N/A
Molecular Weight	1619.87	Flash Point	N/A
Transport Information	N/A	Appearance	While lyophilized powder.
Safety	22-24/25	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Alytesin,2-L-glutamine-6-L-asparagine- (8CI); 108: PN: US20090175821 PAGE: 403 claimedprotein; 25: PN: WO2004075830 SEQID: 25 claimed protein; Bombesin 14;L-Methioninamide,5-oxo-L-prolyl-L-glutaminyl-L-arginyl-L-leucylglycyl-L-asparaginyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-	Article Data	1

Bombesin Synthetic route

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 68858-20-8
Fmoc-Val-OH

: 35661-60-0
Fmoc-Leu-OH

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

: 109425-56-1, 106982-77-8
N-fluoren-9-ylmethyloxycarbonyl-L-pyroglutamine

Fmoc-His(pg)-OH: Fmoc-His(pg)-OH

Fmoc-Trp(pg)-OH: Fmoc-Trp(pg)-OH

Fmoc-Gln(pg)-OH: Fmoc-Gln(pg)-OH

Fmoc-Asn(pg)-OH: Fmoc-Asn(pg)-OH

Fmoc-Arg(pg)-OH: Fmoc-Arg(pg)-OH

: 31362-50-2
Bombesin

Conditions

Conditions	Yield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.583333h; Stage #2: With piperidine In N,N-dimethyl-formamide Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-fluoren-9-ylmethyloxycarbonyl-L-pyroglutamine; Fmoc-His(pg)-OH; Fmoc-Trp(pg)-OH; Fmoc-Gln(pg)-OH; Fmoc-Asn(pg)-OH; Fmoc-Arg(pg)-OH Further stages;	22%

Yield

Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.583333h;
Stage #2: With piperidine In N,N-dimethyl-formamide
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-fluoren-9-ylmethyloxycarbonyl-L-pyroglutamine; Fmoc-His(pg)-OH; Fmoc-Trp(pg)-OH; Fmoc-Gln(pg)-OH; Fmoc-Asn(pg)-OH; Fmoc-Arg(pg)-OH Further stages;

22%

...Expand

Bombesin Chemical Properties

Chemical Name: Bombesin
IUPAC NAME: PyroGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 ; 31362-50-2
CAS No.: 31362-50-2
RTECS: BD3480000
Molecular Formula: C₇₁H₁₁₀N₂₄O₁₈S
Molecular Weight: 1619.85 g/mol
Storage temp.: -20°C
Bombesin (31362-50-2) is a 14-amino acid peptide originally isolated from the skin of a frog. It has two known homologs in mammals called neuromedin B and gastrin releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.Following is the structure:

Product Categories about Bombesin (31362-50-2) are Peptide ; Neuromedins and related
The chemical synonymous of Bombesin (31362-50-2) are Bombesin ; Bombesin acetate hydrate ; Bombesin acetate salt ; Bombesin acoh 7H₂O ; H-PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH₂ ; GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH₂ ; 2-l-Glutamine-6-l-asparagine-alytesin ; Pyr-qrlgnqwavghlm-NH₂

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