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Molecular Structure:
Molecular Formula: C29H42ClNO4
Molecular Weight: 504.1011
IUPAC Name: 2-Methoxy-2-methylpropane
Synonyms of Buprenorphine hydrochloride (CAS NO.53152-21-9): 21-Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine hydrochloride ; Buprenex ; Buprenorphine HCl ; CL 112,302 ; CL 112302 ; EINECS 258-396-8 ; Finibron ; MR 56 ; NIH 8805 ; RX 6029-M ; Subutex ; Temgesic ; UM 952 ; UNII-56W8MW3EN1 ; (5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol hydrochloride ; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (5alpha,7alpha(S))-
CAS NO: 53152-21-9
Classification Code: Analgesic ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect
H bond acceptors: 5
H bond donors: 2
Freely Rotating Bonds: 7
Polar Surface Area: 40.16 Å2
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 79mg/kg (79mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1351, 1984. | |
mammal (species unspecified) | LD50 | intravenous | 40mg/kg (40mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1351, 1984. | |
man | TDLo | oral | 2857ug/kg (2.857mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT | British Medical Journal. Vol. 296, Pg. 214, 1988. |
mouse | LD50 | intramuscular | > 600mg/kg (600mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA BLOOD: CHANGES IN SPLEEN | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
mouse | LD50 | intravenous | 72mg/kg (72mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
mouse | LD50 | oral | 800mg/kg (800mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LIVER: OTHER CHANGES | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
mouse | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN SPLEEN | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
rat | LD50 | intramuscular | > 600mg/kg (600mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BLOOD: CHANGES IN SPLEEN BEHAVIORAL: ATAXIA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
rat | LD50 | intravenous | 62mg/kg (62mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
rat | LD50 | oral | > 1gm/kg (1000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
rat | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN SPLEEN | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982. |
Hazard Codes of Buprenorphine hydrochloride (CAS NO.53152-21-9): Xn
Risk Statements: 22
R22: Harmful if swallowed.
WGK Germany: 3
RTECS: KM7758000
Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
Storage Features of Buprenorphine hydrochloride (CAS NO.53152-21-9).
Treasury ventilated low-temperature drying