- Recycling method of beta,beta-iminodipropionitrile and application
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The invention provides a recycling method of beta,beta-iminodipropionitrile and application, and relates to the technical field of waste recycling. According to the recycling method, by adopting a specific reaction synthesis route, the beta,beta-iminodipropionitrile finally generates calcium pantothenate with wide application, and the recycling method not only reduces hazardous waste emission and treatment and lowers the hazardous waste treatment cost, but also realizes the purpose of turning waste into wealth from beta,beta-iminodipropionitrile, and the utilization value of beta,beta-iminodipropionitrile is greatly improved. The invention further provides application of the recycling method of the beta,beta-iminodipropionitrile, and in view of the advantages of the recycling method of the beta,beta-iminodipropionitrile, a new process route is provided for preparing calcium pantothenate.
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Paragraph 0093; 0098-0099; 0122; 0127-0128; 0132-0136
(2021/05/26)
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- D-calcium pantothenate total synthesis environment-friendly process
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The invention relates to a complete set of new process for synthesizing D-calcium pantothenate. According to the invention, the method comprises the following steps: synthesizing beta-calcium aminopropionate from beta-aminopropionic acid and calcium oxide in water and/or methanol; after filtering, evaporating water and/or methanol in the beta-calcium aminopropionate solution to dryness under negative pressure; or after filtering, stirring and crystallizing for 8-40 hours at the temperature of 20-65 DEG C, filtering again, replacing mother liquor in a re-filtered filter cake with methanol for more than three times, enabling the moisture content in the filter cake to be less than 1%, removing 70% or more of solvent from filtrate, and applying the filtrate to a re-filtering step; soaking beta-calcium aminopropionate with methanol, adding a methanol solution of D-pantolactone, carrying out a reaction at a low temperature, carrying out a reflux reaction to synthesize D-calcium pantothenate,completely or partially evaporating methanol, adding water, dissolving, filtering, transferring into a spray dryer, and carrying out spray drying to obtain the product D-calcium pantothenate. The product quality meets the industrial standard, and the product yield is increased by 15%-20% compared with the existing process level.
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Paragraph 0015-0019
(2020/07/24)
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- Methods for synthesizing Beta-calcium aminopropionate and D-calcium pantothenate
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The invention relates to the field of biochemical engineering, and discloses methods for synthesizing Beta-calcium aminopropionate and D-calcium pantothenate. According to the methods, acrylonitrile is utilized to react with liquid ammonia to prepare Beta-aminopropionitrile; nitrilase is utilized to catalyze to hydrolyze the Beta-aminopropionitrile to generate Beta-aminopropionic acid, afterwards,the Beta-aminopropionic acid reacts with a calcifying agent to synthesize the Beta-calcium aminopropionate, then the Beta-calcium aminopropionate generates an acylation reaction with D-pantolactone,and the D-calcium pantothenate is obtained by filtration and drying. The synthesis methods provided by the invention do not need to use a strong base to hydrolyze the Beta-aminopropionitrile, also donot need to use ion exchange resin to extract the Beta-aminopropionic acid, are used for effectively reducing the generation of a by-product salt, is easily amplified, is used for realizing continuousproduction, and has a quite good industrial application prospect, and a technique is simple, convenient, easy and feasible.
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Paragraph 0049-0054; 0064; 0065; 0066; 0067; 0068; 0069
(2018/06/26)
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- Method for preparing vitamin B5 mechanical grinding solid phase
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The invention relates to a method for preparing a vitamin B5 mechanical grinding solid phase. The method comprises the following steps: uniformly mixing 3-aminopropionic acid with calcium oxide, adding a grinding aid to a ball milling tank at the same time, carrying out ball milling for a certain period of time under the action of the grinding aid, adding D-acidolysis lactone at room temperature after the ball milling, continuing to carry out the ball milling, taking out a reaction mixture after the ball milling is accomplished, dissolving the reaction mixture by using a solvent A, and carrying out recrystallization after rotary evaporation of the solvent A to obtain a target compound vitamin B5. The main innovation point of the invention is that for the vitamin B5 is ground by the ball milling method without solvent for the first time, the original method is generally carried out in the solvent, the use of the solvent in the reaction is omitted by the method provided by the invention, and meanwhile the reaction time is greatly shortened. The method has the advantages of high reaction yield, short reaction time, simple operation and less pollution.
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Paragraph 0017; 0018; 0019; 0020; 0021
(2017/07/19)
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- PROCESS FOR THE SYNTHESIS OF NA- BETA-ALANINATE AND CALCIUM PANTOTHENATE
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In a process for the preparation of Na-β-alaninate from β-amino-propionitrile ready for the condensation with pantolactone to pantothenate the improvement of obtaining Na-β-alaninate as a solution in an alcohol, which improvement comprises carrying out the hydrolysis of β-amino-propionitrile in water and then making a solvent exchange from water to an alcohol, thus achieving that the final β-alaninate mixture contains side- or by-products in amounts only, which do not negatively influence the-pantothenate quality.
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Page/Page column 8; 10; 12-14
(2009/03/07)
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- Calcium pantothenate. Part 3.1 Process for the biologically active enantiomer of the same via selective crystallization and racemization
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Optically pure calcium (R)-pantothenate has been obtained from the racemic compound via direct fractional crystallization of the single enantiomer. Efficient racemization of the biologically inactive calcium (S)-pantothenate without its decomposition to pantolactone has been developed, resulting in a simple, complete, and efficient technology. The results elaborated in the laboratory have been then successfully applied in the industrial scale process.
- Synoradzki, Ludwik,Hajmowiez, Halina,Wisialski, Jerzy,Mizerski, Arkadiusz,Rowicki, Tomasz
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p. 1238 - 1244
(2013/01/03)
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- DNA encoding human κ casein and process for obtaining the protein
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The present invention relates to an expression system comprising a DNA sequence encoding a polypeptide which has a biological activity of human κ-casein, the system comprising a 5′-flanking sequence capable of mediating expression of said DNA sequence. In preferred embodiments the 5′-flanking sequence is from a milk protein gene of a mammal such as a casein gene or whey acidic protein (WAP) gene and the DNA sequence contains at least one intron sequence selected from the intron sequences presented in SEQ ID NO:30. The invention also relates to DNA sequences, replicable expression vectors and cells harboring said vectors, recombinant polypeptide e.g. in glycosylated form, and milk, infant formula or nutrient supplement comprising recombinant polypeptide. The invention further relates to a transgenic non-human mammal such as a mouse, rat, rabbit, goat, sheep, pig, lama, camel or bovine species whose germ cells and somatic cells contain a DNA sequence as defined above as a result of chromosomal incorporation into the non-human mammalian genome, or into the genome of an ancestor of said non-human mammal.
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- Recovery of calcium pantothenate
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Calcium pantothenate is recovered from methanol solution by azeotroping the methanol with a suitable solvent. A methanol solution of calcium pantothenate is added at a regulated rate to a solvent such as octane heated above the methanol boiling point and methanol is removed by distillation as a methanol-solvent azeotrope leaving the calcium pantothenate in the form of a slurry in the azeotroping solvent. The distillation is carried out continuously but the solids may be removed continuously or collected in the still as a batch for subsequent removal.
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- Process for the production of the calcium salt of pantothenic acid
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An improved process for the preparation of dl-calcium pantothenate is described wherein an anhydrous calcium salt of B-Alanine in methanolic solution is reacted with dl-pantolactone directly in a one-step process. The salt of B-Alanine is prepared by reacting acrylonitrile with ammonia, the B-amino-propionitrile formed is hydrolyzed in 50% sodium hydroxide and the sodium salt reacted with a solution of calcium chloride in a liquid which will form an azeotropic mixture with water, any excess sodium hydroxide is neutralized with hydrochloric acid and the water removed by an azeotropic distillation. The reaction mixture is then taken up in methanol and reacted with the dl-pantolactone directly.
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