METHOD OF SCREENING COMPOUND USEFUL IN TREATING ALLERGIC DISEASE
The present invention provides a method of screening for a compound useful for treatment of an allergic disease by identifying a molecule targeted by Intal upon exertion of its efficacy as an anti-allergic agent (hereinafter referred as a target) and using the target, as well as a new type of anti-allergic agent comprising a compound obtainable by the screening as an active ingredient for treatment of an allergic disease.
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Page/Page column 7-8
(2010/04/30)
PREPARATION FOR EXTERNAL APPLICATION COMPRISING SALT OF MAST CELL DEGRANULATION INHIBITOR HAVING CARBOXYL GROUP WITH ORGANIC AMINE
Mast cell degranulation inhibitors having a carboxyl group have not been developed as external preparations due to the low transdermal permeability thereof. By formulating external preparations thereof, side effects on the internal organs by oral administration can be avoided. Some of the mast cell degranulation inhibitors show drastically inferior photostability, which is also one cause of suppressed development of the drug as an external preparation. The present invention aims at improving the transdermal permeability and photostability of mast cell degranulation inhibitors by forming a salt of the mast cell degranulation inhibitor with an organic amine. Consequently, an external preparation of a mast cell degranulation inhibitor can be provided and the photostability of the mast cell degranulation inhibitor itself, and a preparation containing same can be improved.
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Page/Page column 7
(2008/12/07)
NOVEL DRUG DISCOVERY TARGET AND MEDICINE ACTING ON THE SAME
The present invention provides a pharmaceutical composition comprising as an active ingredient a compound that specifically binds to MFP-2 or a functional fragment thereof and a screening method for the compound; the compound and a pharmaceutical composition comprising the same are highly useful as anti-inflammatory agents and anti-allergic agents.
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Page/Page column 12-13
(2008/06/13)
Use of electrolytes (ions in solution) to suppress charging of inhalation aerosols
Formulations are disclosed as are aerosols created therefrom. The formulations are comprised of (a) a pharmaceutically active drug which does not ionize in solution; (b) an electrolyte; and (c) a solvent which is preferably water and/or ethanol. The electrolyte reduces electrostatic charging on particles of aerosol formed thereby enhancing characteristics of the aerosol particles which are important for efficient, repeatable intrapulmonary drug delivery.
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(2008/06/13)
LIPOSOMAL COMPOSITIONS
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(2008/06/13)
Method of treating atopic eczema
The present invention relates to methods of treating chronic skin disorders by externally applying to the skin compounds by the following formula STR1 and therapeutically acceptable salts, esters and amides thereof, wherein R1 through R6 and X are as hereinafter defined.
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(2008/06/13)
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