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CHALCONE

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Name

CHALCONE

EINECS 202-330-2
CAS No. 94-41-7 Density 1.097 g/cm3
PSA 17.07000 LogP 3.58270
Solubility N/A Melting Point 55-59 °C
Formula C15H12O Boiling Point 346.61 °C at 760 mmHg
Molecular Weight 208.26 Flash Point 150.062 °C
Transport Information N/A Appearance light yellow powder
Safety 22-36/37/39-45 Risk Codes 22-36/37
Molecular Structure Molecular Structure of 94-41-7 (CHALCONE) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

Cinnamophenone;NSC 26612;NSC 4523;Phenyl 2-phenylvinyl ketone;Phenyl styryl ketone;Styryl phenyl ketone;a-Benzylideneacetophenone;b-Benzoylstyrene;b-Phenylacrylophenone;1-Phenyl-2-benzoylethylene;2-Benzalacetophenone;2-Benzylideneacetophenone;Chalcone(8CI);1,3-Diphenyl-1-propen-3-one;1,3-Diphenylpropen-3-one;1-Benzoyl-2-phenylethene;Benzylidenecetophenone;

Article Data 474

CHALCONE Chemical Properties

Chalcone's Molecular formula: C15H12O
Chalcone's Molar mass: 208.26 g mol-1
Density: 1.071 g/cm3
Melting point: 55–57 °C
Boiling point: 345-348 °C
Other names: Chalcone;Chalkone;Benzylideneacetophenone;Phenyl styryl ketone
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

CHALCONE Uses

Chalcones show antibacterial, antifungal, antitumor and anti-inflammatory properties.
Some chalcones demonstrated the ability to block voltage-dependent potassium channels.
Chalcones are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities.
Chalcones are also intermediates in the Auwers synthesis of flavones.

CHALCONE Production

Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.

CHALCONE Toxicity Data With Reference

1.   

ivn-mus LD50:56 mg/kg

   CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#04476 .

CHALCONE Consensus Reports

Reported in EPA TSCA Inventory.

CHALCONE Safety Profile

Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.

CHALCONE Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid
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