Basic information
- Name:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1), (6R,7S)-
- Superlist Name:
- Cefmetazole sodium
- CAS No.:
56796-39-5
- Molecular Structure:
![Molecular Structure of 56796-39-5 (5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1), (6R,7S)-)](http://www.lookchem.com/300w/2010/0622/56796-39-5.jpg)
- Formula:
- C15H16N7NaO5S3
- Molecular Weight:
- 493.52
- Synonyms:
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7S)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, (6R-cis)-;CS-1170 sodium salt;Cefmetazole sodium;Cefmetazole-Na;Cefmetazon;Cefmetazone;Metafar;Sodium cefmetazole;Zefazone;
- EINECS:
- 260-384-2
- Appearance:
- White solid
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38-42/43
- Safety Description:
- 26-36 Details
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Chemistry
IUPAC Name: Sodium (6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Systematic of Cefmetazole sodium (CAS NO.56796-39-5): Cefmetazole sodium [USAN:JAN] ; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((((cyanomethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-cis)- ; CMZ sodium ; CS 1170 sodium ; Cefmetazon ; SKF 83088 sodium ; Sodium (6R,7S)-7-(2-((cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate ; U 72791A ; UNII-37Y9VR4W7A ; Zefazone ; Zefazone in plastic container ; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((((cyanomethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, sodium salt, (6R-cis)-
CAS NO: 56796-39-5
Classification Code: Antibacterial ; Drug / Therapeutic Agent ; Reproductive Effect
Molecular Formula of Cefmetazole sodium (CAS NO.56796-39-5): C15H16N7NaO5S3
Molecular Weight: 493.5162
Molecular Structure:
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ProductCategories: Chiral Reagents ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds ; A - KAntibiotics ; Antibacterial ; Antibiotics A to ; Antibiotics A-FAntibiotics ; Chemical Structure Class ; Interferes with Cell Wall SynthesisAntibiotics ; Mechanism of Action ; Penicillins and Cephalosporins (beta-Lactams) ; Spectrum of Activity
H bond acceptors: 12
H bond donors: 2
Freely Rotating Bonds: 9
Polar Surface Area of Cefmetazole sodium (CAS NO.56796-39-5): 230.44 Å2
Uses
Cefmetazole sodium (CAS NO.56796-39-5) is used as antibacterial
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | > 1600mg/kg (1600mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 123, 1980. | |
| mouse | LD50 | intraperitoneal | 10233mg/kg (10233mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 30, Pg. 112, 1978. |
| mouse | LD50 | intravenous | 8690mg/kg (8690mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 30, Pg. 112, 1978. |
| mouse | LD50 | oral | 3228mg/kg (3228mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacobio-Dynamics. Vol. 8, Pg. 633, 1985. |
| mouse | LD50 | subcutaneous | 12190mg/kg (12190mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 30, Pg. 112, 1978. |
| rat | LD50 | intraperitoneal | > 7500mg/kg (7500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 30, Pg. 112, 1978. |
| rat | LD50 | intravenous | > 5gm/kg (5000mg/kg) | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 30, Pg. 112, 1978. | |
| rat | LD50 | oral | 3204mg/kg (3204mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacobio-Dynamics. Vol. 8, Pg. 633, 1985. |
| rat | LD50 | subcutaneous | > 12500mg/kg (12500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 30, Pg. 112, 1978. |
Safety Profile
Hazard Codes: 
Xn,
Xi
Risk Statements: 36/37/38-42/43
R36/37/38: Irritating to eyes, respiratory system and skin.
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 2
RTECS: XI0372200