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| Name |
Chlorcyclizine hydrochloride |
EINECS | 238-335-1 |
| CAS No. | 14362-31-3 | Density | 1.145g/cm3 |
| PSA | 6.48000 | LogP | 4.35460 |
| Solubility | N/A | Melting Point |
226-227 °C |
| Formula | C18H21 Cl N2 . Cl H | Boiling Point | 393.6°Cat760mmHg |
| Molecular Weight | 556.08 | Flash Point | 191.9°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx. | Risk Codes | 61-22 |
| Molecular Structure |
|
Hazard Symbols | T |
| Synonyms |
Piperazine,1-(p-chloro-a-phenylbenzyl)-4-methyl-,monohydrochloride (8CI); Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-methyl-, monohydrochloride (9CI);Chlorcyclizine chloride; Chlorcyclizine hydrochloride; Chlorcyclizinemonohydrochloride; Di-Paralene; Histantin; NSC 169496; Perazil |
Chlorcyclizine hydrochloride Chemical Properties
IUPAC Name: 1-[(4-Chlorophenyl)-phenylmethyl]-4-methylpiperazine hydrochloride
Synonyms of Chlorcyclizine hydrochloride (CAS NO.14362-31-3) : 1-((4-Chlorophenyl)phenylmethyl)-4-methylpiperazine Monohydrochloride ; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-methylpiperazine hydrochloride ; 1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine hydrochloride (1:1) ; Chlorocyclizine hydrochloride ; Diparalene hydrochloride
CAS NO:14362-31-3
Molecular Formula:C18H22Cl2N2
Molecular Weight :337.2867
Molecular Structure :.png)
EINECS: 238-335-1
Flash Point: 191.9 °C
Enthalpy of Vaporization: 64.35 kJ/mol
Boiling Point: 393.6 °C at 760 mmHg
Vapour Pressure: 2.1E-06 mmHg at 25°C
Chlorcyclizine hydrochloride Uses
Chlorcyclizine hydrochloride (CAS NO.14362-31-3) is used as intermediate in organic synthesis.
Chlorcyclizine hydrochloride Production
Raw materials: Etanol-->Hydrochloric acid-->Diethyl ether-->Sulfuric acid -->Sodium carbonate-->Sodium sulfate-->Sodium bicarbonate-->1-Methylpiperazine-->P-XYLENE-->4-Chlorobenzhydrol
Chlorcyclizine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 213, 1972. | |
| dog | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | Compilation of LD50 Values of New Drugs. | |
| guinea pig | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | intravenous | 35mg/kg (35mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | subcutaneous | 200mg/kg (200mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rat | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Compilation of LD50 Values of New Drugs. |
Chlorcyclizine hydrochloride Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When Chlorcyclizine hydrochloride (CAS NO.14362-31-3) is heated to decomposition ,it emits very toxic fumes of HCl and NOx.
Chlorcyclizine hydrochloride Specification
Category: toxic substances
Toxicity classification: highly toxic
Acute toxicity: Oral - Mouse LD50: 300 mg / kg; intraperitoneal - mouse LD50: 100 mg / kg
Flammable hazardous characteristics: thermal decomposition of toxic emissions of nitrogen oxides, chlorine fumes
Storage features: Treasury, low temperature, ventilation, drying; and keep separately from food raw materials
Fire-extinguishing agent: water, carbon dioxide, foam, dry powder
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