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Name	Clobutinol	EINECS	N/A
CAS No.	14860-49-2	Density	1.0373 (rough estimate)
PSA	23.47000	LogP	2.83120
Solubility	N/A	Melting Point	N/A
Formula	C14H22 Cl N O	Boiling Point	bp12 179-180°
Molecular Weight	255.788	Flash Point	N/A
Transport Information	N/A	Appearance	N/A
Safety	Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S..	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Phenethylalcohol, p-chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methyl- (6CI,8CI); 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol;2-(p-Chlorobenzyl)-3-dimethylaminomethyl-2-butanol; Clobutinol

Clobutinol Chemical Properties

IUPAC Name: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
Synonyms of Clobutinol (CAS NO.14860-49-2) : 1-(4-Chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol ; 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol ; 4-Chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylbenzeneethanol ; Biotertussin
CAS NO:14860-49-2
Molecular Formula:C₁₄H₂₂ClNO
Molecular Weight :255.7836
Molecular Structure :
EINECS: 238-926-4
Index of Refraction: 1.53
Surface Tension: 38.3 dyne/cm
Density: 1.072 g/cm³
Flash Point: 169.6 °C
Enthalpy of Vaporization: 63.54 kJ/mol
Boiling Point: 356.8 °C at 760 mmHg
Vapour Pressure: 1.04E-05 mmHg at 25°C

Clobutinol Uses

Clobutinol (CAS NO.14860-49-2) is a cough suppressant.

Clobutinol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	intravenous	45300ug/kg (45.3mg/kg)	Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.
mouse	LD50	intraperitoneal	128mg/kg (128mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse	LD50	intravenous	53mg/kg (53mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse	LD50	oral	334mg/kg (334mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse	LD50	subcutaneous	262mg/kg (262mg/kg)	Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.
rat	LD50	intraperitoneal	165mg/kg (165mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat	LD50	intravenous	63mg/kg (63mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat	LD50	oral	802mg/kg (802mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat	LD50	subcutaneous	775mg/kg (775mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.

Clobutinol Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S..

Clobutinol Specification

Clobutinol (CAS NO.14860-49-2) was recently determined to cause cardiac arrhythmia in some patients.Recent studies have indicated that clobutinol has the potential to prolong the QT interval.Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007

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