Cyclopentanecarboxylicacid, 1-amino-

The IUPAC name of Cycloleucine is 1-aminocyclopentane-1-carboxylic acid. With the CAS registry number 52-52-8, it is also named as Cyclopentanecarboxylic acid, 1-amino-, L-. The product's categories are Pharmacetical; Amino Acids; Amino Acids; Amino Acids & Derivatives; Cycloalkanes, and the other registry number is 15313-85-6. Besides, it is white to beige crystalline flakes or powder, which should be stored in sealed, cool and dry place at room temperature. In addition, its molecular formula is C₆H₁₁NO₂ and molecular weight is 129.16.

The other characteristics of this product can be summarized as: (1)EINECS: 200-144-6; (2)ACD/LogP: -0.05; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -2.55; (5)ACD/LogD (pH 7.4): -2.55; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 3; (11)#H bond donors: 3; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.522; (14)Molar Refractivity: 32.62 cm³; (15)Molar Volume: 106.9 cm³; (16)Surface Tension: 53.2 dyne/cm; (17)Density: 1.207 g/cm³; (18)Flash Point: 108.7 °C; (19)Melting point: 320 °C; (20)Water solubility: 5 g/100 mL; (21)Enthalpy of Vaporization: 54.35 kJ/mol; (22)Boiling Point: 256.1 °C at 760 mmHg; (23)Vapour Pressure: 0.00481 mmHg at 25 °C.

Preparation of Cycloleucine: this chemical can be prepared by 1,3-Diaza-spiro[4.4]nonane-2,4-dione.



This reaction needs 3 N aq. NaOH by heating. The yield is 75 %.

Uses of Cycloleucine:  this chemical is a non-metabolisable amino acid. It is a specific and reversible inhibitor of nucleic acid methylation. It is widely used in biochemical experiments. Additionally, it can react with Ethanol to get 1-Amino-cyclopentanecarboxylic acid ethyl ester.



This reaction needs HCl. The yield is 86.5 %.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed. Please do not breathe dust. And you should avoid contact with skin and eyes.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(O)C1(N)CCCC1
(2)InChI: InChI=1/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
(3)InChIKey: NILQLFBWTXNUOE-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
(5)Std. InChIKey: NILQLFBWTXNUOE-UHFFFAOYSA-N

The toxicity data is as follows: