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Conditions | Yield |
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In water neutralization reaction with stoich. amt. at pH 6-7; |
Conditions | Yield |
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In water |
Conditions | Yield |
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With Pyridine 1-oxide hydrochloride In dichloromethane; water at 18℃; Rate constant; | A 13% B 87% |
Conditions | Yield |
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With tetramethylammonium chloride In water a soln. of Cd salt reated with a soln. of sodium malonate, stirred for 10 min, an aq. mixt. of pyrazine and tetramethylammonium chloride added slowly; filtered, crystd. for 1 wk in an open atmosphere, sepd., washed (H2O), dried; elem. anal.; | 85% |
sodium malonate
Conditions | Yield |
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In tetrahydrofuran under Ar; addn. of freshly prepared sodium malonate in THF to suspn. of Mo-complex in THF (molar ratio 3:1, stirred, 0°C), stirred (15 min, 0°C), quenched (satd. NH4Cl soln.); extn. (CH2Cl2, three times), drying (over Na2SO4), filtration, concn., flash chromy. (1:1 degassed hexanes/ethyl acetate), recrystn. (degassed hexanes/CH2Cl2); elem. anal.; | 82% |
trans-bis(acetonitrile)palladium(II) chloride
water
sodium malonate
Conditions | Yield |
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at 20℃; | 82% |
1,2-bis(4'-pyridyl)ethane
sodium malonate
polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2
Conditions | Yield |
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Stage #1: sodium malonate; Cu(NO3)2.3H2O In methanol; water for 0.5h; Stage #2: 1,2-bis(4'-pyridyl)ethane In methanol; water for 4h; Heating; Further stages.; | 80% |
Conditions | Yield |
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In methanol; water aq. soln. of malonate was added dropwise to MeOH soln. of Mn salt with stirring for 30 min, to this mixt. MeOH soln. of phenanthroline was addedslowly and stirred for 2 h, then refluxed for 6 h; mixt. was cooled, filtered, filtrate was kept in CaCl2-desiccator for several days, ppt. was filtered off, washed and dried; elem. anal.; | 80% |
Conditions | Yield |
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In methanol; water soln. MnCl2*4H2O in MeOH was allowed to react with aq. soln. disodium malonate for 20 min, MeOH soln. 4,4'-bipy was added and stirred for 2 h; soln. was filtered and evapd. slowly, crystals were filtered off, washedwith 2-propanol and dried; elem. anal.; | 80% |
IUPAC Name: Disodium propanedioate (141-95-7)
Synonyms: Malonicacid,sodiumsalt ; Sodiumpropanedioate ; Sodium malonate ; Sodium malonite ; Propanedioic acid disodium salt ; Methanedicarboxylic acid disodium salt ; Malonic acid disodium salt ; Disodium malonate
Molecular Structure:
Molecular Formula : C3H2Na2O4
Molecular Weight: 148.03
CAS : 141-95-7
EINECS: 205-514-0
Flash Point: 201.9 °C
Enthalpy of Vaporization: 69.8 kJ/mol
Boiling Point: 386.8 °C at 760 mmHg
Vapour Pressure: 4.66E-07 mmHg at 25°C
solubility H2O: 1 M at 20 °C, clear, colorless
Stability: Stable. Incompatible with strong oxidizing agents.
Appearance: Sodium malonate (141-95-7) is white crystalline powder
Solution:Soluble in water, insoluble in alcohol, ether and benzene.
Sodium malonate (141-95-7) is used for raw material of pharmaceutical, dye and fragrance ; organic synthesis.
Derive by mixing malonic acid with sodium hydroxide solution; Industrial production often add chloroacetic acid with sodium cyanide to get cyanuric acid, and then through the role of liquid caustic soda sodium malonate. The chloroacetic acid dissolved in water at 15 ℃ below with saturated sodium carbonate solution to pH7.0, and then adding sodium cyanide solution at 45 ℃, at 105-110 ℃ reaction to 30min, adding 45-55% sodium hydroxide, reaction at the 100-105 ℃ 1.5h, concentrated solution of sodium malonic too dry to obtain Sodium malonate (141-95-7).
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1550mg/kg (1550mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949. |
mouse | LD50 | intravenous | 2100mg/kg (2100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949. |
rabbit | LD50 | intravenous | 660mg/kg (660mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949. |
rabbit | LDLo | subcutaneous | 1584mg/kg (1584mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD ENDOCRINE: HYPERGLYCEMIA | Journal of Biological Chemistry. Vol. 161, Pg. 55, 1945. |
rat | LD50 | intraperitoneal | 1100mg/kg (1100mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 814, 1965. |
Safety Statements: 22-24/25
22: Sodium malonate (141-95-7) is harmful if swallowed
24/25: Toxic in contact with skin and if swallowed
WGK Germany: 3
RTECS: OO1750000