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Etofenamate

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Name Etofenamate EINECS
CAS No. 30544-47-9 Density
Solubility Melting Point
Formula C18H18 F3 N O4 Boiling Point
Molecular Weight 369.37 Flash Point
Transport Information Appearance
Safety Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F and NOx. See also FLUORIDES. Risk Codes
Molecular Structure Molecular Structure of 30544-47-9 (Benzoic acid,2-[[3-(trifluoromethyl)phenyl]amino]-, 2-(2-hydroxyethoxy)ethyl ester) Hazard Symbols
Synonyms

Anthranilicacid, N-(a,a,a-trifluoro-m-tolyl)-, 2-(2-hydroxyethoxy)ethyl ester (8CI);2-(2-Hydroxyethoxy)ethyl flufenamate;2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid 2-(2-hydroxyethoxy)ethylester; B 577; Bay-d 1107; Bayrogel; Etofenamate; Glasel; Reumon; Rheumon;Rheumon gel; TV 485; Traumon Gel; WHR 5020

 

Chemistry

IUPAC Name: 2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
Molecular Formula:C18H18F3NO4
Molecular Weight: 369.335 g/mol
EINECS: 250-231-8
Boiling Point:130–135°C
Apperance: oil
Partition Coefficient: Log P 4.99 (calc).
Structure of   Etofenamate (CAS NO. 30544-47-9):      
Product Category : Fluorides.

Uses

Etofenamate(CAS NO. 30544-47-9) is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs relieve pain and reduce the inflammation and fever produced by the body's immune system. Etofenamate has been successfully used for a number a years to treat patients with acute or chronic rheumatic diseases.
 

Toxicity Data With Reference

1.    

orl-rat LD50:292 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
2.    

ipr-rat LD50:373 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
3.    

scu-rat LD50:568 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
4.    

ivn-rat LD50:139 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
5.    

orl-mus LD50:743 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
6.    

scu-mus LD50:1897 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
7.    

ivn-mus LD50:75 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
8.    

scu-rbt LD50:1532 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F and NOx. See also FLUORIDES.

Analytical Methods

Uv max (methanol): 286 (E1%1cm 423). nD25 1.564.

Specification

 Etofenamate  its cas register number is 30544-47-9. It also can be called n-(Alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid  ; 2-(2-hydroxyethoxy)  ; 2-(2-Hydroxyethoxy)ethyl 2-[ [3-(trifluoromethyl)phenyl]amino]benzoate ; Rheumon ; TV-485 .
It is hazardous. Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. When  Etofenamate (CAS NO. 30544-47-9) is heated to decomposition, it emits very toxic fumes of F and NOx. So keep the prodct in cool place, and put it away from fire.

 

 

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