1. Introduction of Imatinib mesylate
Imatinib mesylate is off-white solid. The IUPAC Name of this chemical is Methanesulfonic acid; 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. In addition, its Classification Code is Antineoplastic. Besides, Imatinib mesylate belongs to Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Tyrosine Kinase Inhibitors. Imatinib mesylate is soluble in aqueous buffers ≤ pH 5.5 but is very slightly soluble to insoluble in neutral/alkaline aqueous buffers.

2. Properties of Imatinib mesylate
Physical properties about Imatinib mesylate are:
(1)H-Bond Donor: 3; (2)H-Bond Acceptor: 10; (3)Flash Point: 410.3 °C; (4)Enthalpy of Vaporization: 115.42 kJ/mol; (5)Boiling Point: 754.9 °C at 760 mmHg; (6)Vapour Pressure of Imatinib mesylate (CAS NO.220127-57-1): 6.03E-24 mmHg at 25 °C.

3. Structure Descriptors of Imatinib mesylate
(1)Canonical SMILES: C1N(C)CCN(C1)Cc1ccc(cc1)C(Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C)=O.OS(C)(=O)=O
(2)InChI: InChI=1/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
(3)InChIKey: InChIKey=YLMAHDNUQAMNNX-UHFFFAOYSA-N 
(4)Smiles: C1N(C)CCN(C1)Cc1ccc(cc1)C(Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C)=O.OS(C)(=O)=O

4. Uses of Imatinib mesylate
Imatinib mesylate (CAS NO.220127-57-1) is used as a tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It can inhibits Bcr-Abl protein-tyrosine kinase.

As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans.