Basic information
- Name:
Imatinib mesylate
- CAS No.:
220127-57-1
- Molecular Structure:
- Formula:
- C29H31N7O.CH4O3S
- Molecular Weight:
- 589.71
- Synonyms:
- Benzamide, 4-[ (4-methyl-1-piperazinyl)methyl]-N-[[4- methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, monomethanesulfonate;Matinib mesylate;Imatinib Methanesulfonate;Imatinibmesylate & its intermediates;4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide methanesulfonic acid salt;Veenat;4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3- (4-pyridin-3-yl)-pyrimidin-2-ylamino)-phenyl]-benzamidemethanesulf onic acid salt;methanesulfonic acid; 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;
- Boiling Point:
- 754.9 °C at 760 mmHg
- Flash Point:
- 410.3 °C
- Appearance:
- Off-white solid
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Chemistry
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IUPAC Name: Methanesulfonic acid; 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Molecular Formula: C29H31N7O.CH4O3S
Molecular Weight: 589.71 g/mol
Canonical SMILES: C1N(C)CCN(C1)Cc1ccc(cc1)C(Nc1ccc(c(c1)Nc1nccc(n1)c1cccnc1)C)=O.OS(C)(=O)=O
InChI: InChI=1/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
Classification Code: Antineoplastic
Product Categories: Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Tyrosine Kinase Inhibitors
H-Bond Donor: 3
H-Bond Acceptor: 10
Flash Point: 410.3 °C
Enthalpy of Vaporization: 115.42 kJ/mol
Boiling Point: 754.9 °C at 760 mmHg
Vapour Pressure of Imatinib mesylate (CAS NO.220127-57-1): 6.03E-24 mmHg at 25 °C
Uses
Imatinib mesylate (CAS NO.220127-57-1) is used as a tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).
Specification
Imatinib mesylate (CAS NO.220127-57-1), its Synonyms are Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-, monomethanesulfonate ; 4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide methanesulfonate ; 4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate . It is off-white solid.