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L-5-Hydroxytryptophan

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Name

L-5-Hydroxytryptophan

EINECS 224-411-1
CAS No. 4350-09-8 Density 1.484 g/cm3
Solubility slightly soluble in water Melting Point 270 °C (dec.)(lit.)
Formula C11H12N2O3 Boiling Point 520.6 °C at 760 mmHg
Molecular Weight 220.23 . Flash Point 268.7 °C
Transport Information UN 2811 6.1/PG 3 Appearance white to pale grey powder
Safety 36-26 Risk Codes 22-36/37/38-65-20/21/22-20/21
Molecular Structure Molecular Structure of 4350-09-8 (L-Tryptophan,5-hydroxy-) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

Tryptophan,5-hydroxy-, L- (8CI);(S)-5-Hydroxytryptophan;5-Hydroxy-L-tryptophan;5-Hydroxyl-L-tryptophan;Cincofarm;L-5-HTP;Levothym;Levotinine;Oxitriptan;Oxyfan;Pretonine;Quietim;Serotonyl;Telesol;Tript-Oh;

 

L-5-Hydroxytryptophan Chemical Properties

Molecular Formula: C11H12N2O3
Molecular Weight: 220.22
EINECS: 224-411-1
Flash piont: 175 °F
Refractive index: n20/D 1.4850(lit.)
Melting Point: 270 °C (dec.)(lit.)
Density: 0.902 g/mL at 25 °C(lit.)
Appearance: White to pale grey powder
Alpha: -32.5 º (c=1,H2O on dry basis)
Melting point: 270 °C (dec.)(lit.)
Storage tempreture: 2-8 °C
Water solubility: 10 mg/mL
Appearance: Colorless to pale pink crystals
Structure of L-5-Hydroxytryptophan (CAS NO.4350-09-8):
                      
IUPAC Name: (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
Canonical SMILES: C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
Isomeric SMILES: C1=CC2=C(C=C1O)C(=CN2)C[C@@H](C(=O)O)N
InChI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
InChIKey: LDCYZAJDBXYCGN-VIFPVBQESA-N
Product Category of L-5-Hydroxytryptophan (CAS NO.4350-09-8): Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Biochemicals Found in Plants;Nutrition Research;Tryptophan Derivatives;Unnatural Amino Acid Derivatives

L-5-Hydroxytryptophan Uses


 L-5-Hydroxytryptophan (CAS NO.4350-09-8) is used as an antidepressant, appetite suppressant, and sleep aid.

L-5-Hydroxytryptophan Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 298mg/kg (298mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
mouse LD50 intravenous 375mg/kg (375mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
mouse LD50 oral 1708mg/kg (1708mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
mouse LD50 subcutaneous 418mg/kg (418mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rabbit LD50 oral 285mg/kg (285mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rat LD50 intraperitoneal 91mg/kg (91mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
rat LD50 intravenous 27mg/kg (27mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rat LD50 oral 243mg/kg (243mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
rat LD50 subcutaneous 149mg/kg (149mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.

L-5-Hydroxytryptophan Safety Profile

Safety Information of L-5-Hydroxytryptophan (CAS NO.4350-09-8):
Hazard Codes: XnIrritantXiIrritant
Risk Statements: 22-36/37/38-65-20/21/22-20/21
 R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R65: Harmful: may cause lung damage if swallowed. 
R20/21: Harmful by inhalation and in contact with skin.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36-26
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YN7110000
HazardClass: 6.1
PackingGroup: III
HS Code: 29339990

L-5-Hydroxytryptophan Specification

 L-5-Hydroxytryptophan , its cas register number is 4350-09-8. It also can be called 5-Hydroxy-L-tryptophan ; Oxitriptan ; Tript-OH ; and L-Tryptophan, 5-hydroxy- . L-5-Hydroxytryptophan (CAS NO. 4350-09-8) is a naturally occurring amino acid, and is a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. It is marketed in the United States and other countries as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. However, according to a 2001 meta-analysis, no sufficient high quality research has been done to establish its effectiveness for treatment of clinical depression or dysthymia.

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