Melphalan

Structure of Melphalan (CAS NO.148-82-3):

IUPAC Name: (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid 
Empirical Formula: C₁₃H₁₈Cl₂N₂O₂
Molecular Weight: 305.2002 
EINECS: 205-726-3 
Index of Refraction: 1.596
Molar Refractivity: 78.77 cm³
Molar Volume: 231.2 cm³
Polarizability: 31.22×10^-24cm³
Surface Tension: 55.2 dyne/cm
Density: 1.32 g/cm³
Flash Point: 239.9 °C
Enthalpy of Vaporization: 77.55 kJ/mol 
Melting Point: ~180 °C
Boiling Point: 473.1 °C at 760 mmHg
Vapour Pressure: 9.33E-10 mmHg at 25°C 
Water Solubility: <0.1 g/100 mL at 22 ºC 
Physical Appearance: Crystalline Solid
Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals

 Melphalan (CAS NO.148-82-3) is used to treat multiple myeloma and ovarian cancer, and occasionally malignant melanoma. The agent was first investigated as a possible drug for use in melanoma. It was not found to be effective, but has been found to be effective in the treatment of myeloma.

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 239.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 ,1975,p. 167.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: mouse, rat RRCRBU    Recent Results in Cancer Research. 52 (1975),1. . EPA Genetic Toxicology Program.

Confirmed human carcinogen producing leukemia and Hodgkin′s disease. Poison by ingestion, intravenous, and intracerebral routes. Human systemic effects by ingestion: nausea, hypermotility, diarrhea, agranulocytosis, thrombocytopenia. Human reproductive effects by ingestion: menstrual changes. Mutation data reported. A skin irritant. Used as a poison gas. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x.
Hazard Codes: T+
Risk Statements: 45-46-26/27/28-63 
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed. 
R63:Possible risk of harm to the unborn child.
Safety Statements: 53-22-36/37/39-45 
S53:Avoid exposure - obtain special instructions before use. 
S22:Do not breathe dust. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: AY3675000
F: 8
HazardClass: 6.1(a)
PackingGroup: II

  Melphalan , its cas register number is 148-82-3. It also can be called 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine ; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine ; Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L- ; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine ; L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine ; L-Phenylalanine mustard ; L-Sarcolysin ; Phenylalanine mustard ; Phenylalanine nitrogen mustard ; p-Bis(beta-chloroethyl)aminophenylalanine ; p-Di-(2-chloroethyl)amino-L-phenylalanine ; p-L-Sarcolysin ; p-N-Bis(2-chloroethyl)amino-L-phenylalanine .