Product Name: Mitomycin C
Synonyms: (1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate ; [(1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methylcarbamat ; [1aS-(1aa,8b,8aa,8ba)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione ; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-[(hydroxyiminomethoxy)methyl]-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)- ;azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)- ;carbamate de [(1aS,8S,8aR,8bS)-6-amino-8a-méthoxy-5-méthyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroaziréno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]méthyle ;MitoExtra ;Mito-medac ;Mitomycin C derivative ;Mitomycin derivative
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Molecular Structure:
Molecular Formula : C₁₅H₁₈N₄O₅
Molecular Weight: 334.33
CAS NO: 50-07-7
EINECS : 200-008-6
Merck : 13,6236
Index of Refraction: 1.68
Surface Tension: 77.2 dyne/cm
Density: 1.56 g/cm³
Flash Point: 305.6 °C
Enthalpy of Vaporization: 86.99 kJ/mol
Boiling Point: 581.8 °C at 760 mmHg
Vapour Pressure: 1.59E-13 mmHg at 25°C
Melting point : 360 ºC
Water solubility : soluble
Storage temp. 2-8°C
Solubility H2O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple
Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
Blue-Violet Crystals
 

 Mitomycin C (CAS NO.50-07-7) is an antitumor antibiotic.

 Raw materials :Dichloromethane-->streptomyces avermifilis
 Mitomycin C (CAS NO.50-07-7) is obtained by the separation and purification of inoculum of the soil actinomycete strain .

 Hazard Codes T,T+,Xn
Risk Statements 25-40-22-45-26/27/28
R25 :Toxic if swallowed.
R40:Limited evidence of a carcinogenic effect.
R22:Harmful if swallowed.
R45:May cause cancer.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements 36/37-45-28-53-22
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S28:After contact with skin, wash immediately with plenty of soap-suds.
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS CN0700000
F 8-10
HazardClass 6.1(a)
PackingGroup II

1.General Description :Blue-violet crystals. Used as an anti-tumor antibiotic complex.
2.Air & Water Reactions :Water soluble.
3.Reactivity Profile: Mitomycin C is sensitive to prolonged exposure to light. Mitomycin C may be sensitive to prolonged exposure to air. Mitomycin C is incompatible with strong oxidizing agents, strong acids and strong bases. Calcium salts may cause decomposition.
4.Health Hazard: Toxic doses as low as 750 mg/kg have been reported in humans. The major toxic effect is myelosuppression, characterized by marked leukopenia and thrombocytopenia; this may be delayed and cumulative. Interstitial pneumonia and glomerular damage resulting in kidney failure are unusual but well documented complications. Lung conditions -- administration of mitomycin has been recognized as causing pneumonitis, alveolitis and pulmonary fibrosis. Kidney conditions -- administration of Mitomycin Can cause kidney damage. Kidney toxicity was observed in 1-5 percent of patients. Depressed immune conditions.
5.Fire Hazard :Flash point data for Mitomycin C are not available; however, Mitomycin C is probably combustible.