Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

N-Methylphthalimide

Related Products

Hot Products

Name

N-Methylphthalimide

EINECS 208-982-4
CAS No. 550-44-7 Density 1.314 g/cm3
PSA 37.38000 LogP 0.85030
Solubility N/A Melting Point 129-132 °C(lit.)
Formula C9H7NO2 Boiling Point 286 °C at 760 mmHg
Molecular Weight 161.16 Flash Point 117.4 °C
Transport Information N/A Appearance N/A
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 550-44-7 (N-Methylphthalimide) Hazard Symbols IrritantXi
Synonyms

1H-Isoindole-1,3(2H)-dione, 2-methyl-;5-21-10-00273 (Beilstein Handbook Reference);1H-Isoindole-1, 3 (2H)-dione, 2-methyl-;Phthalimide, N-methyl-;2-Methyl-isoindole-1,3-dione;

Article Data 169

N-Methylphthalimide Synthetic route

67-56-1

methanol

136918-14-4

phthalimide

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With bis-(2-(1-adamantyl)ethyl) azodicarboxylate; triphenylphosphine Mitsunobu reaction;100%
With bis(3-(perfluoro-t-butyloxy)propyl)diazodicarboxylate; bis-phenyl-[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl]phosphine In tetrahydrofuran at 20℃; Mitsunobu reaction; Inert atmosphere;95%
With PhP(C6H4-p-(CH2)2C6F13)2; diethylazodicarboxylate In tetrahydrofuran91%
19532-98-0

N1,N2-dimethylphthalamide

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With hydrogenchloride at 20℃; under 750.06 Torr; Cyclization; solid-gas reaction;100%
With water
at 190℃;
at 190℃;
136918-14-4

phthalimide

431-47-0

trifluoroacetic acid-methyl ester

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With sodium methylate; sodium hydride In dimethyl sulfoxide at 20℃; for 10h;100%
136918-14-4

phthalimide

50-00-0

formaldehyd

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With hydrogenchloride; hydrogen In water at 75 - 80℃; pH=5.5; Temperature; Concentration; Autoclave; Inert atmosphere;99.33%
at 150 - 160℃;
85-44-9

phthalic anhydride

74-89-5

methylamine

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
In water at 120 - 180℃; for 0.333333h; Autoclave; Inert atmosphere;99%
In ethanol; toluene for 3h; Solvent; Reflux;95%
In water91%
4702-13-0

N-phthaloylglycine

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With acrylonitrile; β‐cyclodextrin In acetonitrile UV-irradiation; Inert atmosphere;97%
With potassium carbonate In water; acetone at 15℃; Irradiation;95%
In acetonitrile for 1h; Kinetics; Mechanism; Irradiation; Variation of solvents, irradiation times and methods.;94%
136918-14-4

phthalimide

616-38-6

carbonic acid dimethyl ester

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine In N,N-dimethyl-formamide at 95℃; for 8h;95%
88-67-5

2-Iodobenzoic acid

201230-82-2

carbon monoxide

74-89-5

methylamine

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With triethylamine In toluene at 100℃; under 760.051 Torr; for 4h; Autoclave;95%
64-18-6

formic acid

58084-22-3

2-iodo-N-methyl-benzamide

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With iodine; palladium diacetate; triethylamine; triphenylphosphine In toluene at 80℃; for 2h;95%
88070-48-8

N-methylbenzamide

201230-82-2

carbon monoxide

550-44-7

N-methylphthalimide

Conditions
ConditionsYield
With potassium dihydrogenphosphate; Cp*Rh(MeCN)3[ClO4]2; silver carbonate In tert-Amyl alcohol at 100℃; under 760.051 Torr; for 24h;94%

N-Methylphthalimide Consensus Reports

Reported in EPA TSCA Inventory.

N-Methylphthalimide Specification

The N-Methylphthalimide is an organic compound with the formula C9H7NO2. The IUPAC name of this chemical is 2-methylisoindole-1,3-dione. With the CAS registry number 550-44-7, it is also named as 1H-Isoindole-1,3(2H)-dione, 2-methyl-. The product's categories are API Intermediates; N-Substituted Maleimides, Succinimides & Phthalimides; N-Substituted Phthalimides; Cyclic ImidesDerivatization Reagents; Carbonyl Compounds; Derivatization Reagents HPLC; Organic Building Blocks; UV-VIS. Besides, it should be stored in a cool and well-ventilated place.

Physical properties about N-Methylphthalimide are: (1)ACD/LogP: 1.56; (2)ACD/LogD (pH 5.5): 1.56; (3)ACD/LogD (pH 7.4): 1.56; (4)ACD/BCF (pH 5.5): 8.96; (5)ACD/BCF (pH 7.4): 8.96; (6)ACD/KOC (pH 5.5): 167.26; (7)ACD/KOC (pH 7.4): 167.26; (8)#H bond acceptors: 3; (9)Polar Surface Area: 37.38 Å2; (10)Index of Refraction: 1.607; (11)Molar Refractivity: 42.35 cm3; (12)Molar Volume: 122.5 cm3; (13)Polarizability: 16.78×10-24cm3; (14)Surface Tension: 52 dyne/cm; (15)Density: 1.314 g/cm3; (16)Flash Point: 117.4 °C; (17)Enthalpy of Vaporization: 52.51 kJ/mol; (18)Boiling Point: 286 °C at 760 mmHg; (19)Vapour Pressure: 0.00271 mmHg at 25°C.

Preparation: this chemical can be prepared by phthalimide and methanol. This reaction will need reagent PhP(C6H4-p-(CH2)2C6F13)2, DEAD and solvent tetrahydrofuran. The yield is about 91%.



Uses of N-Methylphthalimide: it can be used to produce N-bromomethyl-phthalimide at temperature of 160 - 170 °C. It will need reagent bromine.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C2c1ccccc1C(=O)N2C
(2)InChI: InChI=1/C9H7NO2/c1-10-8(11)6-4-2-3-5-7(6)9(10)12/h2-5H,1H3
(3)InChIKey: ZXLYYQUMYFHCLQ-UHFFFAOYAF
(4)Std. InChI: InChI=1S/C9H7NO2/c1-10-8(11)6-4-2-3-5-7(6)9(10)12/h2-5H,1H3
(5)Std. InChIKey: ZXLYYQUMYFHCLQ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD oral > 500mg/kg (500mg/kg)   National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 23, 1953.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 550-44-7