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Name |
N-Methyl-L-prolinol |
EINECS | 251-981-9 |
CAS No. | 34381-71-0 | Density | 0.973 g/cm3 |
PSA | 23.47000 | LogP | 0.01080 |
Solubility | N/A | Melting Point |
N/A |
Formula | C6H13NO | Boiling Point | 164.8 °C at 760 mmHg |
Molecular Weight | 115.175 | Flash Point | 63.3 °C |
Transport Information | N/A | Appearance | white to light yellow crystal powder |
Safety | 23-24/25-36-26 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
2-Pyrrolidinemethanol,1-methyl-, (S)-;(-)-(S)-1-Methyl-2-pyrrolidinemethanol;(2S)-(Hydroxymethyl)-1-methylpyrrolidine;(2S)-1-Methylpyrrolidin-2-ylmethanol;(2S)-1-Methylpyrrolidine-2-methanol;(S)-(-)-(1-Methyl-2-pyrrolidinyl)methanol;(S)-(-)-1-Methylpyrrolidine-2-methanol;(S)-(-)-2-Hydroxymethyl-1-methylpyrrolidine;(S)-1-Methyl-2-pyrrolidinemethanol;(S)-1-Methylpyrrolidin-2-ylmethanol;(S)-2-(Hydroxymethyl)-1-methylpyrrolidine;(S)-N-Methylpyrrolidine-2-methanol;L-(-)-N-Methyl-2-pyrrolidinylmethanol;L-N-Methylprolinol;2-Pyrrolidinemethanol,1-methyl-, (2S)-; |
Article Data | 31 |
(S)-N-(tert-butoxycarbonyl)proline methyl ester
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether | 90% |
formaldehyd
(S)-1-Pyrrolidin-2-yl-methanol
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With formic acid In water for 20h; Heating; | 65% |
With formic acid; water anschliessenden Erhitzen; | |
With hydrogen; platinum(IV) oxide In water for 24h; | 2.4 g |
With formic acid | |
With formic acid Yield given; |
N-methyl-L-proline
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Heating; | 65% |
L-proline
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With aq. sodium hydroxide; acetic anhydride In tetrahydrofuran; formic acid; water | 57% |
Multi-step reaction with 2 steps 1: NaBH4, H2SO4 2: HCOOH View Scheme | |
Multi-step reaction with 2 steps 1: NaBH4, conc. H2SO4 2: HCOOH View Scheme | |
Multi-step reaction with 2 steps 1: acetic anhydride / 2 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 48 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 94 percent / H2O 2: 95 percent / diethyl ether 3: 90 percent / 3 eq. LiAlH4 / diethyl ether View Scheme |
N-Methyl-L-proline Methyl Ester
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
53% | |
With lithium aluminium tetrahydride In tetrahydrofuran |
N-Benzyloxycarbonyl-L-proline
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran 1.) room temp., 1 h, 2.) reflux, 3 h; | 49% |
Conditions | Yield |
---|---|
Stage #1: formic acid; L-proline With acetic anhydride Stage #2: With lithium aluminium tetrahydride | 48% |
(2S)-1-formylpyrrolidine-2-carboxylic acid
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 48h; Heating; Yield given; |
N-carbobenzyloxy-L-proline methyl ester
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride |
N-methylproline
A
(R)-N-methylpyrrolidine-2-methanol
B
(S)-2-hydroxymethyl-1-methylpyrrolidine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran Heating; Title compound not separated from byproducts; |
Molecule structure of N-Methyl-L-prolinol (CAS NO.34381-71-0):
IUPAC Name: (1-Methylpyrrolidin-2-yl)methanol
Molecular Weight: 115.17352 g/mol
Molecular Formula: C6H13NO
Density: 0.973 g/cm3
Boiling Point: 164.8 °C at 760 mmHg
Flash Point: 63.3 °C
Index of Refraction: 1.468
Molar Refractivity: 32.95 cm3
Molar Volume: 118.3 cm3
Surface Tension: 32.2 dyne/cm
Enthalpy of Vaporization: 46.74 kJ/mol
Vapour Pressure: 0.649 mmHg at 25 °C
Storage Temp.: −20 °C
XLogP3-AA: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 1
Exact Mass: 115.099714
MonoIsotopic Mass: 115.099714
Topological Polar Surface Area: 23.5
Heavy Atom Count: 8
Canonical SMILES: CN1CCCC1CO
InChI: InChI=1S/C6H13NO/c1-7-4-2-3-6(7)5-8/h6,8H,2-5H2,1H3
InChIKey: VCOJPHPOVDIRJK-UHFFFAOYSA-N
EINECS: 251-981-9
Product Categories: chiral;Chiral Reagent
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-36-26
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
F: 8-10-23
Hazard Note: Irritant
N-Methyl-L-prolinol (CAS NO.34381-71-0) is also named as (1-Methyl-2-pyrrolidinyl)methanol ; (1-Methylpyrrolidin-2-yl)methanol ; 2-Pyrrolidinemethanol, 1-methyl- ; 1-Methyl-2-pyrrolidinemethanol ; 1-Methylpyrrolidine-2-Methanol . N-Methyl-L-prolinol (CAS NO.34381-71-0) is white to light yellow crystal powder.