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Conditions | Yield |
---|---|
Stage #1: indole-2,3-dione With hydrazine In methanol Heating; Stage #2: With sodium ethanolate In ethanol Wolff-Kishner reduction; Heating; Further stages.; | 98% |
With hydrogen In ethanol at 70℃; under 1875.19 Torr; for 0.333333h; | 96.5% |
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.0833333h; Temperature; Reagent/catalyst; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With iron; acetic acid at 100℃; | 95% |
With palladium on activated charcoal; hydrogen; acetic acid at 20℃; for 4h; | 88% |
With 5%-palladium/activated carbon; hydrogen In ethanol; water under 7500.75 Torr; for 24h; Autoclave; | 88% |
methyl (2-nitrophenyl)acetate
2-oxoindole
Conditions | Yield |
---|---|
Stage #1: methyl (2-nitrophenyl)acetate With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 24h; Autoclave; Stage #2: In ethyl acetate for 6h; Reflux; Molecular sieve; | 99% |
With iron; ammonium chloride; acetic acid at 100℃; for 24h; | 87.8% |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 2280.15 Torr / Sealed tube 2: ethyl acetate / 6 h / Reflux; Molecular sieve View Scheme |
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 1h; | A 44% B 8% |
With oxygen; titanium(IV) oxide In water for 4h; Irradiation; | |
With D-glucose; GDH; cytochrome P450 monooxygenase CYP116B4 from Labrenzia aggregata; nicotinamide adenine dinucleotide phosphate In aq. buffer at 30℃; for 5h; pH=8.5; Enzymatic reaction; | |
With nicotinamide adenine dinucleotide phosphate; cytochrome P450 monooxygenase from Labrenzia aggregata In aq. buffer at 30℃; for 5h; pH=8.5; Enzymatic reaction; enantioselective reaction; |
1-(toluene-4-sulfonyl)-1,3-dihydro-indol-2-one
2-oxoindole
Conditions | Yield |
---|---|
With naphthalene radical anion sodium salt In 1,2-dimethoxyethane at -78 - 18℃; Reagent/catalyst; | 90% |
Conditions | Yield |
---|---|
With chloro[2-nitro-5,10,15,20-tetrakis(2,6-diclorophenyl)porphyrinate]manganese(III); chloro[5,10,15,20-tetrakis(4-dimethy-lamino-2,3,5,6-tetrafluorophenyl)porphyrinate]manganese(III) In acetonitrile at 20℃; for 0.5h; | A 35% B 7% |
With ammonium persulfate; phosphoric acid In water pH=1.4; Oxidation; | A 26% B 32% |
ethyl 2-nitrophenylacetate
2-oxoindole
Conditions | Yield |
---|---|
With acetic acid; zinc In ethanol at 70℃; for 4h; Inert atmosphere; | 93% |
With acetic acid; zinc In ethanol at 70℃; for 4h; | 66% |
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 0.5h; | A 64% B 7% C 6% |
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); chloro[2-nitro-5,10,15,20-tetrakis(2,6-diclorophenyl)porphyrinate]manganese(III) In acetonitrile at 20℃; for 0.5h; | A 50% B 6% C 6% |
N'-(2-aminobenzylidene)-4-methylbenzenesulfonohydrazide
molybdenum hexacarbonyl
2-oxoindole
Conditions | Yield |
---|---|
With tetraethylammonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20 - 110℃; for 1h; Solvent; Reagent/catalyst; | 83% |
IUPAC Name:1,3-dihydroindol-2-one
Molecular Formula:C8H7NO
Molecular Weight:133.147280 g/mol
Melting Point:123-128 °C(lit.)
Boiling Point:227 °C73 mm Hg(lit.)
Flash Point:194-196°C/17mm
Insolubility:Water
EINECS:200-429-5
BRN:114692
CAS DataBase Reference:59-48-3(CAS DataBase Reference)
NIST Chemistry Reference:59-48-3(NIST)
EPA Substance Registry:System 59-48-3(EPA Substance)
Synonyms of 2-OXINDOLE(59-48-3):
OXINDOL;OXINDOLE;O-(AMINOPHENYL)ACETIC ACID LACTAM;TIMTEC-BB SBB004215;1,3-dihydro-2h-indol-2-on;1,3-Dihydro-indol-2-one;1,3-Dihydroindol-2-one;2,3-dihydroindol-2-one;Oxindole
Categories of 2-OXINDOLE(59-48-3):
blocks;IndolesOxindoles;Aromatic Phenylacetic Acids and Derivatives;Indoles and derivatives;Indoline & Oxindole;Indoles;Indole Derivatives