Detail of "120-72-9"

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CAS Number:
120-72-9
Name:
Indole
Molecular Structure:
Formula:
C₈H₇N
Molecular Weight:
117.16
Synonyms:
2,3-Benzopyrrole;1-Benzo(b)pyrrole;1H-indole;1-Azaindene;Benzopyrrole;2, 3-Benzopyrrole;Indole 99%min;Indole perfume;Indole industrial;Indole Crystal;1-Benzazole;2,3-Benzopyrole;Ketole;Benzo[b]pyrrole;3-benzopyrrole; 1H-indole;
EINECS:
204-420-7
Density:
1.22 g/cm³
Melting Point:
51-54 °C(lit.)
Boiling Point:
253 °C at 760 mmHg
Flash Point:
107.839 °C
Solubility:
methanol: 0.1 g/mL, clear
Appearance:
white crystals with an unpleasant odour
Hazard Symbols:
Xn,N,T
Risk Codes:
21/22-37/38-41-50/53-36-39/23/24/25-23/24/25
Safety:
26-36/37/39-60-61-45-36/37 Details
Transport Information:
UN 2811 6.1/PG 3

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Reference

Soluble polymer-supported synthesis of indoles via palladium-mediated heteroannulation of terminal alkynes with o-iodoanilines: Soluble polymer-supported synthesis of indoles via palladium-mediated heteroannulation of terminal alkynes with o-iodoanilines. Lin, Xu Feng; Ma, Cheng; Yang, Ye Wei; Wang, Yan Guang ( Department of Chemistry, Zhejiang University, Hangzhou 310027, Peop. Rep. China). Chinese Chemical Letters, 13(8), 705-707 (English) 2002 Chinese Chemical Society. CODEN: CCLEE7. ISSN: 1001-8417.In this experiment, several chemicals are used like 94-09-7 DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) A sol. polymer-supported synthesis of indoles via palladium-mediated heteroannulation of terminal alkynes with o-iodoanilines has been described. The protocol provides a useful tool for constructing combinatorial indole libraries. Treatment of 4-amino-3-iodobenzoic acid with polyethylene glycol mesylate gave the desired polyethylene glycol-supported 4-amino-3-iodobenzoic acid. Activation of the amino group was achieved by methylsulfonylation, thus yielding polyethylene glycol-supported 3-iodo-4-[(methylsulfonyl)amino]benzoic acid (I); activation of the amino group was required for the subsequent cyclization with terminal alkynes. The cyclization of I with 1-hexyne gave polymer-bound 2-butyl-1-(methylsulfonyl)-1H-Indole-5-carboxylic acid Me ester which was cleaved from the support to yield 2-butyl-1H-Indole-5-carboxylic acid Me ester. .

(4-Phenylpropyl)indole derivatives and their salts and their use as medicines: (4-Phenylpropyl)indole derivatives and their salts and their use as medicines. Clemence, Francois; Guillaume, Jacques; Hamon, Gilles (Roussel-UCLAF , Fr.). Eur. Pat. Appl. EP 201400 A1 17 Dec 1986, 49 pp. DESIGNATED STATES: R: AT, BE, CH, DE, GB, IT, LI, LU, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: C07D209-08. ICS: C07D209-34; A61K031-40. APPLICATION: EP 86-400884 23 Apr 1986. PRIORITY: FR 85-6135 23 Apr 1985; FR 86-761 21 Jan 1986. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds. [I; R, R1 = H, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl; NRR1 may be part of a heterocycle contg. O or N; R2 = H, alkyl; X = OH, H, Y = H or XY = O; R3R4 = O and R5 = H, or R3R5 = bond and R4 = H] and their salts, useful as antiarrhythmics and Ca antagonists, are prepd. 1H-Indole-4-carboxaldehyde was treated with 1-[2-[2-(tert-butylamino)ethoxy]phenyl]ethanone in EtOH contg. NaOH for 4 h to give (E)-4-[3-[2-(tert-butylamino)ethoxy]phenyl]-3-oxo-2-propenyl]-1H-indole. Administration of I to rats (0.05-1 mg/kg i.v.In this study，109920-69-6 is also used. or 0.25-2.5 mg/kg orally) delayed the onset of aconitine-induced arrhythmia by 25-56%. .

Detail of "120-72-9"

Indole

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CAS No.120-72-9 Indole

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CAS No.120-72-9 Indole

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CAS No.120-72-9 Indole

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CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

CAS No.120-72-9 Indole

Reference