Reference

Biological studies on indole derivatives

Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives. Khan, Muhammad Tahir Javed; Ashraf, Muhammad; Alam, Mahbub; Lone, Khalid P. (Fac. Pharm., Univ. Punjab, Lahore, Pak.). Acta Physiol. Pharmacol. Latinoam., 36(4), 391-5 (English) 1986. CODEN: APPLEF. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27 3-Hydroxy-3-acetonyloxindole (I) [33417-17-3] was prepd. by reaction of isatin [91-56-5] with Me2CO [67-64-1], and 3-acetonylideneoxindole (II) [6524-20-5] was prepd. by dehydration of I. The pharmacol. and toxicol. effects of I and II were studied in rabbits. Both drugs induced changes in serum enzyme [L-alanine-2-oxoglutarate aminotransferase (EC 2.6.1.2) and L-aspartate-2-oxoglutarate aminotransferase (EC 2.6.1.1)] and cholesterol levels, indicating profound changes in liver function. Both drugs decreased the Hb content of the blood, but the mechanism by which this occurred is unclear.

Structure and antihypoxic activity of a-dicarbonyl compounds and their derivatives

Structure and antihypoxic activity of a-dicarbonyl compounds and their derivatives. Tomchin, A. B.; Aleksandrova, A. E.; Vinogradov, V.Chemical with cas number 91-56-5 also plays role. M. (Leningrad, USSR). Farmakol. Toksikol. (Moscow), 41(4), 482-91 (Russian) 1978. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The antihypoxic activity of 29 a-dicarbonyl compds. was studied in rats with hypoxic hypoxia and was related to the structure, redox potential, and dehydrating activity of the compd. The most active compds. had redox potentials in the 0.15-0.3 V range and they had high dehydrating activity. Such compds. included isatin (I) [91-56-5], its 3-anyl [33828-98-7], and acenaphthequinone [82-86-0]. Substitutions at positions 1 and 3 of isatin led to formation of active substances, whereas substitution at position 2 decreased antihypoxic effectiveness. .