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MF: C3H6N2O6
MW: 166.09
EINECS: 229-180-0
Flash Point: 98.5 °C
Melting Point: -30°C
Storage temp: Flammables area
Density: 1.37 g cm-3 at 20°C.
Enthalpy of Vaporization: 42.49 kJ/mol
Boiling Point: 206.7 °C at 760 mmHg
Vapour Pressure: 0.336 mmHg at 25°C
IUPAC Name: 1-nitrooxypropan-2-yl nitrate
Solubility: Slightly soluble in water (7.97 g L-1 H2O at 24.85°C).
Chemical Properties: Colorless liquid with a disagreeable odor
Synonyms: 1,2-Bis-(nitryloxy)-propane ; 1,2-Bis-nitryloxy-propane ; Dinitratedepropylene ; Isopropylene nitrate ; PGDN ; Propylene dinitrate ; Propylene glycol 1,2-dinitrate ; Propylene glycol dinitrate
Following is the molecular structure of Propylene glycol dinitrate (6423-43-4):
Reactivity Profile: Propylene glycol dinitrate (6423-43-4) is explosive. Acts as a strong oxidizing agent. Heating may cause a violent combustion or explosion producing toxic fumes (nitrogen oxides). May also decompose explosively from shock, friction or from a build-up of electrostatic charge that sparks suddenly to ground. Can begin a vigorous reaction that culminates in an explosion if mixed with reducing agents including hydrides, sulfides, and nitrides and numerous ordinary combustible materials. Reacts violently with Al, BP, cyanides, esters, PN2H, P, NaCN, SnCl2, sodium hypophosphite, and thiocyanates. Reacts with acids and with alkalis, including ammonia and amines. Must be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials.
1. | eye-rbt 100 mg MLD | TXAPA9 Toxicology and Applied Pharmacology. 22 (1972),128. | ||
2. | ihl-hmn TCLo:200 ppb/6H:CNS | TXAPA9 Toxicology and Applied Pharmacology. 30 (1974),377. | ||
3. | ihl-hmn TCLo:1500 ppb/5M:EYE | TXAPA9 Toxicology and Applied Pharmacology. 30 (1974),377. | ||
4. | orl-rat LD50:250 mg/kg | AIHAAP American Industrial Hygiene Association Journal. 34 (1973),526. | ||
5. | scu-rat LD50:463 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 15 (1969),175. | ||
6. | ipr-rat LD50:479 mg/kg | AIHAAP American Industrial Hygiene Association Journal. 34 (1973),526. | ||
7. | scu-mus LD50:1208 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 15 (1969),175. | ||
8. | ipr-mus LD50:1047 mg/kg | AIHAAP American Industrial Hygiene Association Journal. 34 (1973),526. | ||
9. | ivn-mky LDLo:410 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 22 (1972),128. | ||
10. | scu-cat LDLo:200 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 15 (1969),175. | ||
11. |
Reported in EPA TSCA Inventory.
Poison by ingestion and subcutaneous routes. Moderately toxic by intraperitoneal and intravenous routes. Human systemic effects by inhalation: conjunctiva irritation, headache. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.
OSHA PEL: TWA 0.05 ppm
ACGIH TLV: TWA 0.05 ppm (skin)
DFG MAK: 0.05 ppm (0.34 mg/m3)
The principal current use of propylene glycol dinitrate(6423-43-4) is as a propellant in Otto Fuel II, together with 2-nitrodiphenylamine and dibutyl sebacate. Otto Fuel II is used in some torpedoes as a propellant.
Nitrates of polyhydric alcohols, of which propylene glycol dinitrate is an example, have been used in medicine for the treatment of angina pectoris, and as explosives since the mid-nineteenth century.
PGDN affects blood pressure, causes respiratory toxicity, damages liver and kidneys, distorts vision, causes methoglobinuria, and can cause headache and lack of coordination. It may be absorbed through skin. Its primary toxicity mechanism is methemoglobinemia. It may cause permanent nerve damage. One of the byproducts of its burning is a highly toxic cyanide gas.