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Name	Paramethasone acetate	EINECS	216-486-4
CAS No.	1597-82-6	Density	1.29 g/cm1.29 g/cm3
PSA	100.90000	LogP	2.32240
Solubility	N/A	Melting Point	228-241° (dec)
Formula	C24H31 F O6	Boiling Point	584.2 °C at 760 mmHg
Molecular Weight	434.505	Flash Point	307.1 °C
Transport Information	N/A	Appearance	N/A
Safety	Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of F⁻.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Pregna-1,4-diene-3,20-dione,6a-fluoro-11b,17,21-trihydroxy-16a-methyl-, 21-acetate(6CI,7CI,8CI); 16a-Methyl-6a-fluoroprednisolone 21-acetate;21-Acetoxy-6a-fluoro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione;21-Acetyl-6a-fluoro-16a-methylprednisolone; 6a-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione21-acetate; 6a-Fluoro-16a-methylprednisolone 21-acetate;Alondra; Cortidene; Dilar; Dillar; Flumethone; Haldrate; Haldrone; Metilar;Monocortin; Paramethasone 21-acetate; Paramethasone acetate; Paramezone;Stemex; Syntecort

Paramethasone acetate Synthetic route

: 1524-93-2
21-acetoxy-6α-fluoro-11β,17-dihydroxy-16α-methyl-pregn-4-ene-3,20-dione

: 1597-82-6
paramethasone acetate

Conditions

Conditions	Yield
With selenium(IV) oxide

: 3862-45-1
21-acetoxy-3,3-ethanediyldioxy-6β-fluoro-16α-methyl-5α-pregn-17(20)t-ene-5,11β-diol

: 1597-82-6
paramethasone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 4-methyl-morpholine; H2O2; OsO4 / anschliessend mit HCl in CHCl3 und Aethanol 2: SeO2 View Scheme

: chromium chloride hexahydrate

: 9α-Bromo-6α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

: 1597-82-6
paramethasone acetate

Conditions

Conditions	Yield
With zinc In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone

: 1597-82-6
paramethasone acetate

: 2823-42-9
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-21-acetoxypregna-1,4-diene-3,20-dione

Conditions

Conditions	Yield
ueber mehrere Stufen;

Paramethasone acetate Chemical Properties

Molecule structure of Paramethasone acetate (CAS NO.1597-82-6):

IUPAC Name: [2-[(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Molecular Weight: 434.497743 g/mol
Molecular Formula: C₂₄H₃₁FO₆
Density: 1.29 g/cm³
Boiling Point: 584.2 °C at 760 mmHg
Flash Point: 307.1 °C
Index of Refraction: 1.569
Molar Refractivity: 109.76 cm³
Molar Volume: 334.8 cm³
Polarizability: 43.51×10^-24 cm³
Surface Tension: 52.3 dyne/cm
Enthalpy of Vaporization: 100.22 kJ/mol
Vapour Pressure: 4.42E-16 mmHg at 25 °C
XLogP3: 2.5
H-Bond Donor: 2
H-Bond Acceptor: 7
Rotatable Bond Count: 4
Tautomer Count: 2
Exact Mass: 434.210467
MonoIsotopic Mass: 434.210467
Topological Polar Surface Area: 101
Heavy Atom Count: 31
Complexity: 895
Defined Atom StereoCenter Count: 9
Canonical SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)COC(=O)C)O)C)O)C)F
Isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)C)F
InChI: InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21-,22+,23+,24+/m1/s1
InChIKey: HYRKAAMZBDSJFJ-LFDBJOOHSA-N
EINECS of Paramethasone acetate (CAS NO.1597-82-6): 216-486-4

Paramethasone acetate Toxicity Data With Reference

ipr-rat LD50:392 mg/kg

TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185.

Paramethasone acetate Safety Profile

Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of F⁻.

Paramethasone acetate Specification

Paramethasone acetate (CAS NO.1597-82-6) is also called 16-alpha-Methyl-6-alpha-fluoro-prednisolone-21-acetate ; 21-Acetyl-6-alpha-fluoro-16-alpha-methylprednisolone ; 6-alpha-Fluoro-16-alpha-methylprednisolone 21-acetate ; 6alpha-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate ; Acetate de paramethasone ; Alondra ; Cortidene ; Dilar ; Haldrate ; Haldrone ; Monocortin ; Paramethasone 21-acetate ; Sintecort ; Stemex ; UNII-8X50N88ZDP .

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