N-(4-methylphenyl)-N~2~-[(4-methylphenyl)sulfonyl]glutamine

Base Information

• Chemical Name: N-(4-methylphenyl)-N~2~-[(4-methylphenyl)sulfonyl]glutamine
• CAS No.: 7465-68-1
• Molecular Formula: C₁₉H₂₂N₂O₅S
• Molecular Weight: 390.46
• Mol file: 7465-68-1.mol

Synonyms:NSC404242

Chemical Property of N-(4-methylphenyl)-N~2~-[(4-methylphenyl)sulfonyl]glutamine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.325g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-methylphenyl)-N~2~-[(4-methylphenyl)sulfonyl]glutamine

There total 4 articles about N-(4-methylphenyl)-N~2~-[(4-methylphenyl)sulfonyl]glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.12%

p-toluidine (106-49-0,12221-03-3) + 1-((4-methylbenzene)sulfonyl)-5-oxopyrrolidine-2-carboxylic acid (6970-25-8) → 2-(4-methylphenylsulfonamido)-5-((4-methylphenyl)amino)-5-oxopentanoic acid (7465-68-1)

Guidance literature:

In benzene; Cooling with ice;

DOI:10.3329/bjp.v10i1.20748

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-(4-methylphenylsulfonamido)-5-((4-methylphenyl)amino)-5-oxopentanoic acid (7465-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide

2: acetyl chloride / benzene / 4 h / Reflux

3: benzene / Cooling with ice

With acetyl chloride; sodium hydroxide; In benzene;

DOI:10.3329/bjp.v10i1.20748

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → 2-(4-methylphenylsulfonamido)-5-((4-methylphenyl)amino)-5-oxopentanoic acid (7465-68-1)

Guidance literature:

Multi-step reaction with 4 steps

1: chlorosulfonic acid / 0 - 20 °C

2: sodium hydroxide

3: acetyl chloride / benzene / 4 h / Reflux

4: benzene / Cooling with ice

With chlorosulfonic acid; acetyl chloride; sodium hydroxide; In benzene;

DOI:10.3329/bjp.v10i1.20748

upstream raw materials:

p-toluidine

1-((4-methylbenzene)sulfonyl)-5-oxopyrrolidine-2-carboxylic acid

p-toluenesulfonyl chloride

toluene