N-(4-NITROPHENYL)MALEIMIDE

Base Information

• Chemical Name: N-(4-NITROPHENYL)MALEIMIDE
• CAS No.: 4338-06-1
• Molecular Formula: C10H6N2O4
• Molecular Weight: 218.169
• Hs Code.: 2925190090
• Mol file: 4338-06-1.mol

Synonyms:Maleimide,N-(p-nitrophenyl)- (6CI,7CI,8CI);1-(4-Nitrophenyl)-1H-pyrrole-2,5-dione;N-(4-Nitrophenyl) maleimide;N-(p-Nitrophenyl)maleimide;NSC 39726;NSC 55656;p-Nitrophenylmaleimide;

Chemical Property of N-(4-NITROPHENYL)MALEIMIDE

Chemical Property:

• Melting Point: 170 °C
• Boiling Point: 418.5 °C at 760 mmHg
• PKA: -5.19±0.20(Predicted)
• Flash Point: 206.9 °C
• PSA: 83.20000
• Density: 1.535 g/cm³
• LogP: 1.61240

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 22
• Safety Statements: 23-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-NITROPHENYL)MALEIMIDE

There total 14 articles about N-(4-NITROPHENYL)MALEIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(Z)-3-(4-nitro-phenylcarbamoyl)-acrylic acid (36342-10-6) → N-(4-nitrophenyl)maleimide (4338-06-1)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; triethylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1016/j.tet.2005.10.027

Reference yield: 91.0%

4-nitro-aniline (100-01-6,104810-17-5) + maleic acid (110-16-7,26099-09-2) → N-(4-nitrophenyl)maleimide (4338-06-1)

Guidance literature:

With PPA; at 80 ℃; for 12h;

DOI:10.1016/S0040-4039(03)00167-9

Reference yield: 89.0%

3-chloro-1-(4-nitrophenyl)pyrrolidine-2,5-dione (37904-11-3) → N-(4-nitrophenyl)maleimide (4338-06-1)

Guidance literature:

With triethylamine; In acetone; for 3h;

upstream raw materials:

4-(4-nitrophenylamino)-4-oxobut-2-enoic acid

N-phenyl-maleimide

1-(4-nitrophenyl)pyrrole-2-carbaldehyde

(Z)-3-(4-nitro-phenylcarbamoyl)-acrylic acid

Downstream raw materials:

(4aS,5aS,8aR,8bS)-3,4a-Dimethyl-7-(4-nitro-phenyl)-4a,5a,8a,8b-tetrahydro-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6,8-dione

5-(p-Nitrophenyl)-3-(2-furoyl)-4,6-dioxo-4,6,7,8-tetrahydropyrrolo<3,4-d>-Δ²-pyrazoline

Refernces

• 1、 Kul'nevich,Baum,Goldovskaya. "Oxidation of 1-(4-nitrophenyl)-2-formylpyrrole". . p. 375 - 379. Retrieved 1982.
• 2、 Koohgard, Mehdi,Hosseinpour, Zeinab,Hosseini-Sarvari, Mona. "Dual organic dyes as a pseudo-redox mediation system to promotion of tandem oxidation /[3+2] cycloaddition reactions under visible light". . . Retrieved 2021/05/10.
• 3、 -. "Thermally Sensitive Protecting Groups for Cysteine, and Manufacture and Use Thereof". Paragraph 0086; 0089-0090. . Retrieved 2021/02/12.