Pentanenitrile, 2-methyl-2-[(trimethylsilyl)oxy]-

Base Information

• Chemical Name: Pentanenitrile, 2-methyl-2-[(trimethylsilyl)oxy]-
• CAS No.: 91390-80-6
• Molecular Formula: C9H19NOSi
• Mol file: 91390-80-6.mol

Synonyms:

Chemical Property of Pentanenitrile, 2-methyl-2-[(trimethylsilyl)oxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanenitrile, 2-methyl-2-[(trimethylsilyl)oxy]-

There total 1 articles about Pentanenitrile, 2-methyl-2-[(trimethylsilyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trimethylsilyl cyanide (7677-24-9) + 2-Pentanone (107-87-9) → 2-Hydroxy-2-methyl-pentanenitrile (4111-09-5) + 2-methyl-2-(trimethylsiloxy)pentanenitrile (91390-80-6)

Guidance literature:

With trimethylsilyl bis(trifluoromethanesulfonyl)imide; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1080/00397919608003546

Reference yield: 90.0%

p-phenoxyphenylmagnesium chloride + 2-methyl-2-(trimethylsiloxy)pentanenitrile (91390-80-6) → C12H16O2

Guidance literature:

at 20 - 70 ℃; for 4h;

Reference yield: 52.0%

4-phenoxyphenylmagnesium bromide (21473-02-9) + 2-methyl-2-(trimethylsiloxy)pentanenitrile (91390-80-6) → C12H16O2

Guidance literature:

at 20 - 70 ℃; for 4h;

upstream raw materials:

trimethylsilyl cyanide

2-Pentanone

Downstream raw materials:

(S)-methyl propyl ketone cyanohydrin

(R)-methyl propyl ketone cyanohydrin

Refernces