5-Bromo-2-tert-butylpyridine

Base Information

• Chemical Name: 5-Bromo-2-tert-butylpyridine
• CAS No.: 39919-58-9
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Hs Code.: 2933399090
• Mol file: 39919-58-9.mol

Synonyms:5-bromo-2-tert-butylpyridine

Chemical Property of 5-Bromo-2-tert-butylpyridine

Chemical Property:

• Vapor Pressure: 0.102mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 230 °C at 760 mmHg
• Flash Point: 92.9 °C
• PSA: 12.89000
• Density: 1.293 g/cm³
• LogP: 3.14160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-bromo-2-tert-butylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-tert-butylpyridine

There total 4 articles about 5-Bromo-2-tert-butylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-iodo-5-bromopyridine (223463-13-6) + 2,2-dimethylpropylmagnesium chloride (13132-23-5) → 5-bromo-2-(tert-butyl)pyridine (39919-58-9)

Guidance literature:

2,2-dimethylpropylmagnesium chloride; With copper(l) cyanide; In tetrahydrofuran; at -78 ℃; for 1h;

2-iodo-5-bromopyridine; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 50.0%

2-iodo-5-bromopyridine (223463-13-6) → 5-bromo-2-(tert-butyl)pyridine (39919-58-9)

Guidance literature:

tert-butylmagnesium chloride; With copper(II) cyanide; In tetrahydrofuran; at -78 ℃; for 1.5h;

2-iodo-5-bromopyridine; In tetrahydrofuran; at -78 - 20 ℃; for 17h;

Reference yield: 38.0%

2-iodo-5-bromopyridine (223463-13-6) + tert-butylmagnesium chloride (677-22-5) → 5-bromo-2-(tert-butyl)pyridine (39919-58-9)

Guidance literature:

tert-butylmagnesium chloride; With copper(l) cyanide; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

2-iodo-5-bromopyridine; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

upstream raw materials:

2-iodo-5-bromopyridine

tert-butylmagnesium chloride

tert-butylmagnesium bromide

2-Cyano-5-bromopyridine

Downstream raw materials:

2-cyano-6-(1,1-dimethylethyl)pyridine

Refernces

• 1、 -. "MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR". Page/Page column 716. . Retrieved 2021/02/10.
• 2、 -. "HETEROARYL DERIVATIVES AND USES THEREOF". Paragraph 0231; 0232. . Retrieved 2014/05/20.